| Construction and expression of the single-chain Fv gene specific for humanγ-seminoprotein |
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| 引用本文： | 武国军,郝晓柯,王禾,白玉杰,张盈华,药立波,范金水.Construction and expression of the single-chain Fv gene specific for humanγ-seminoprotein[J].中国人民解放军军医大学学报,1999(4). |
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| 作者姓名： | 武国军 郝晓柯 王禾 白玉杰 张盈华 药立波 范金水 |
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| 作者单位： | Department of Urology，Xijing Hospital，Central Laboratory，Tangdu Hospital，Department of Biochemistry，Fourth Military Medical University，Xi'an，710032 |
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| 摘 要： | Y-seminoproteinisanantigenspecificforprostatecancer1].PreliminarydatafromaphaseItrialinwhichprostatecancerpatientshavere-ceivedl31I-labledanti-humanY-seminoproteinmon-oclonalantibody(McAb)indicatethatthelabeledantibodylocalizedwelltotumor2].ButtheMcAbisrodent.MurineMcAbsforhumancancerthera-pyarelimited,especiallywhentheyarerepeatedlyadministeredinthattheyusuallyelicitanimmuneresponseinbodyasforimmungenicitytohuman.Asinglechainvariablefragment(ScFv)moleculeisdefinedasarecombinantproteinc…
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