| Effect of simulated ischemia-reperfusion on If in sinoatrial node cells and theintervention of KATP channel opener |
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| 作者姓名： | 宋治远 仝识非 钟理 |
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| 作者单位： | Department of Cardiology，Southwest Hospital，Third Military Medical University，Chongqing 400038，China，Department of Cardiology，Southwest Hospital，Third Military Medical University，Chongqing 400038，China，Department of Cardiology，Southwest Hospital，Third Military Medical University，Chongqing 400038，China |
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| 基金项目： | Supported by National Natural Science Foundation of China (No.30070314) |
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| 摘 要： | Objective: To study the effect of simulated ischemia-reperfusion (I/R) on If of sinoatrial node (SAN) cells and the intervention of KATP channel opener Pinacidil. Methods: The SAN cells of the neonatal rats were detached and purified 2 d before the experiment. The experimental animals were randomly divided into the control group, group of simulated I/R, group intervened with KATP channel opener Pinacidil (P+ I/R) and group intervened with KATP channel blocking agent 5-HD (5-HD + P + I/R & 5-HD + I/R). The If density of each group was measured by technique of routine whole cell patch clamp and multiple-catheter perfusion system and the If activated curve in each group was drawn. Results: ①Under different directive potentials, the If density of the SAN cells in I/R group increased significantly, compared with that in the control group ( P < 0.01); that in P + I/R group decreased significantly, compared with that in I/R group ( P < 0.01); the If density values in 5-HD + P + I/R group and 5-HD + I/R group i
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| 关 键 词： | 局部缺血 多次灌注液 窦房结细胞 干预作用 KATP通道 电生理学 |
Effect of simulated ischemia-reperfusion on If in sinoatrial node cells and the intervention of KATP channel opener |
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| SONG Zhi-yuan TONG Shi-fei ZHONG Li.Effect of simulated ischemia-reperfusion on If in sinoatrial node cells and theintervention of KATP channel opener[J].Journal of Medical Colleges of PLA(China),2004,19(6):325-328. |
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| Authors: | SONG Zhi-yuan TONG Shi-fei ZHONG Li |
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| Institution: | SONG Zhi-yuan TONG Shi-fei ZHONG Li Department of Cardiology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | |
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| Keywords: | sinoatrial node ischemia-reperfusion If KATP channel patch clamp technique |
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