Clinico-pathological Features of Chronic Asymptomatic Hepatitis B Virus Infection in High Prevalence Area

From a population with high hapatitis B virus(HBV)infection,289liver biopsies were performed,including39cases of chronic asymptomatichepatitis(ASH),218 chronic asymptomatic carrier(AsC),10 transientcarriers and22cases after ending of carrier status.Among AsC,therewere 7.3% of chronic active hepatiti(CAH),22.0% of chronic persistenthepatitis(CPH),10.6% of chronic lobular hepatitis(CLH),48.2% of mi-nimal changes,and 11.9% of normal liver histology.The pathologicalchanges of AsH were more severe,that of transient carriers milder andsome after carrier status cases had still remained chronic hepatitis.Among257cases with chronic HBV infection there were 26(10.1%)asymptomaticCAH,and 61(23.7%)asymptomatic CPH,their importance in the compo-sition of HBV infections was emphasied.48.2% of AsC were the cases ofminimal changes,which might be a quite stable status of hypo-reactivity toprolonged HBV infection.From the above results,the clinico-pathologicalfeatures of HBV infection in high pravalence area might be:numerousasymptomatic infections and hypo-reactive type of infection status,but highfrequency of liver lesions,although most of them were mild.

Clinico-pathological Features of Chronic Asymptomatic Hepatitis B Virus Infection in High Prevalence Area

From a population with high hapatitis B virus(HBV)infection,289 liver biopsies were performed,including39cases of chronic asymptomatic hepatitis(ASH),218 chronic asymptomatic carrier(AsC),10 transient carriers and22cases after ending of carrier status.Among AsC,there were 7.3% of chronic active hepatiti(CAH),22.0% of chronic persistent hepatitis(CPH),10.6% of chronic lobular hepatitis(CLH),48.2% of mi- nimal changes,and 11.9% of normal liver histology.The pathological changes of AsH were more severe,that of transient carriers milder and some after carrier status cases had still remained chronic hepatitis.Among 257cases with chronic HBV infection there were 26(10.1%)asymptomatic CAH,and 61(23.7%)asymptomatic CPH,their importance in the compo- sition of HBV infections was emphasied.48.2% of AsC were the cases of minimal changes,which might be a quite stable status of hypo-reactivity to prolonged HBV infection.From the above results,the clinico-pathological features of HBV infection in high pravalence area might be:numerous asymptomatic infections and hypo-reactive type of infection status,but high frequency of liver lesions,although most of them were mild.