| Sodium Ion Transport by Erythrocytes in hypertensives and Its Response to Antihypertensive Therapy |
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| 作者姓名： | 祝之明 宋克群 刘光耀 李言让 徐有奇 |
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| 作者单位： | Laboratory of Hypertensive Disease Daping Hospital Third Military Medical College Chongqing，Laboratory of Hypertensive Disease Daping Hospital Third Military Medical College Chongqing，Laboratory of Hypertensive Disease Daping Hospital Third Military Medical College Chongqing，Laboratory of Hypertensive Disease Daping Hospital Third Military Medical College Chongqing，Laboratory of Hypertensive Disease Daping Hospital Third Military Medical College Chongqing |
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| 摘 要： | The transport of sodium ions by erythrocytes and the plasma level of endogenous digitalis-like compound (EDLC) were assessed in 59 patients with essential hypertension before and after theadminstration of nifedipine and prazosin. 20 normal subjects were studied similarly and served as con-trol. It was found that (1) EH patients had a pronounced defect of both the active and passive trans-port of sodium ions by the erythrocytes; (2) a higher plasma level of EDLC was detected in EH pa-tients as compared with that of the control, but the changes of EDLC and soudium pump were notparallel; (3) after the administration of nifedipine and prazosin, the function of sodium pump wasmarkedly improved and the plasma level of EDLC decreased. In addition, the relationship betweenthe transport of sodium ions by erythrocytes and the pathogenesis of EH, and the effects of anti-hypertensive agents were discussed.
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Sodium Ion Transport by Erythrocytes in hypertensives and Its Response to Antihypertensive Therapy |
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| Zhu Zhimingy,Song Kequn,Liu Guanyao,Li yanrang,Xiu Youqi,Laboratory of Hypertensive Disease,Daping Hospital,Third Military Medical College,Chongqing.Sodium Ion Transport by Erythrocytes in hypertensives and Its Response to Antihypertensive Therapy[J].Journal of Medical Colleges of PLA(China),1989(3). |
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| Authors: | Zhu Zhimingy Song Kequn Liu Guanyao Li yanrang Xiu Youqi Laboratory of Hypertensive Disease Daping Hospital Third Military Medical College Chongqing |
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| Abstract: | The transport of sodium ions by erythrocytes and the plasma level of endogenous digitalis- like compound (EDLC) were assessed in 59 patients with essential hypertension before and after the adminstration of nifedipine and prazosin. 20 normal subjects were studied similarly and served as con- trol. It was found that (1) EH patients had a pronounced defect of both the active and passive trans- port of sodium ions by the erythrocytes; (2) a higher plasma level of EDLC was detected in EH pa- tients as compared with that of the control, but the changes of EDLC and soudium pump were not parallel; (3) after the administration of nifedipine and prazosin, the function of sodium pump was markedly improved and the plasma level of EDLC decreased. In addition, the relationship between the transport of sodium ions by erythrocytes and the pathogenesis of EH, and the effects of anti- hypertensive agents were discussed. |
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| Keywords: | essential hypertension erythrocyte antihypertensive agent transport of sodium ions endogenous digitalis-like compound |
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