| Physicochemical variations of malondialdehyde－and Cu~（2＋）－modified low density lipoprotein |
| |
| 引用本文： | 丁振华,陈瑗,周玫,方允中.Physicochemical variations of malondialdehyde－and Cu~（2＋）－modified low density lipoprotein[J].中国人民解放军军医大学学报,1995(2). |
| |
| 作者姓名： | 丁振华 陈瑗 周玫 方允中 |
| |
| 作者单位： | Ding Zhenhua;Chen Yuan;Zhou Mei;Fang Yunzhong(Research Group of Lipoperoxidative Damage，First Military Medical University，Guangzhou，510515;Institute of Radiation Medicine，Academy of Military Medical Sciences，Beijing，100850 |
| |
| 摘 要： | Ｐｈｙｓｉｃｏｃｈｅｍｉｃａｌｖａｒｉａｔｉｏｎｓｏｆｍａｌｏｎｄｉａｌｄｅｈｙｄｅ－ａｎｄＣｕ~（２＋）－ｍｏｄｉｆｉｅｄｌｏｗｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎＤｉｎｇＺｈｅｎｈｕａ（丁振华）；ＣｈｅｎＹｕａｎ（陈瑗）；ＺｈｏｕＭｅｉ（周玫）；?..
|
Physicochemical variations of malondialdehyde-and Cu~(2+)-modified low density lipoprotein |
| |
| Ding Zhenhua,Chen Yuan,Zhou Mei,Fang Yunzhong.Physicochemical variations of malondialdehyde-and Cu~(2+)-modified low density lipoprotein[J].Journal of Medical Colleges of PLA(China),1995(2). |
| |
| Authors: | Ding Zhenhua Chen Yuan Zhou Mei Fang Yunzhong |
| |
| Abstract: | After Modification of low density lipoprotein(LDL) by either malondialdehyde(MDA) or Cu2+,its thiobarbituric acid reactive substances(TBARS),lipid conjugated dienes,and relative electrophoretic mobility(REM) levels,and the fluorescence emission spectra were measured.There was a strong lipoperoxidative reaction during the Cu2+ modification but not in the MDA modification.The REM was found increased after both modifications which indicated that the negative charges on apo B-100 were obviously increased.The fluorescence emission spectra of modified LDL showed that the emission intensity was gradually increased as the modification reaction goes on but their maximum wavelength and the spectra patterns were not the same,this showed that the fluorescence chromophores were not identical.These findings may be of some significance in the study of modified LDL's antigenicity and scavenger receptor multiplicity. |
| |
| Keywords: | low density lipoprotein lipoperoxidation malondialdehyde |
| 本文献已被 CNKI 等数据库收录！ |
