新疆地区狼疮肾炎患者尿液单核细胞趋化因子1水平及临床意义

目的探讨狼疮肾炎（lupus nephritis，LN）患者尿液中单核细胞趋化因子1（monocyte chemoattractant protein 1，MCP-1）的水平及其临床意义。方法采用横断面调查研究分析方法，ELISA法检测33例活动期狼疮肾炎患者和35例缓解期狼疮肾炎患者尿液中 MCP-1水平。结果活动期狼疮肾炎患者 MCP-1水平468．0（205～1990）pg/mg Cr]明显高于缓解期狼疮肾炎患者131．5（69～734）pg/mg Cr]，差异有统计学意义（P ＝0．000）。活动期狼疮肾炎组患者年龄（25．9±3．7）岁，缓解期狼疮肾炎组患者年龄（29．7±3．5）岁，两组年龄有统计学差异（P ＜0．05），活动期狼疮肾炎组患者抗 ds-DNA抗体阳性率高于缓解期狼疮肾炎组患者（P ＜0．05）。两组在性别和族别上无统计学差异（P ＞0．05）。活动期狼疮肾炎组患者尿液中MCP-1水平与24 h尿蛋白定量及24 h尿白蛋白/肌酐（Urinary albumin-to-creatinine，UACR）呈正相关（r＝0．916，P＝0．000；r＝0．936，P＝0．000）。结论活动期狼疮肾炎患者尿液中 MCP-1水平升高，对狼疮肾炎的活动性及复发具有可靠稳定的临床诊断意义。需进行前瞻性研究进一步明确其临床意义。

The levels of urinary monocyte chemoattractant protein 1 and clinical significance in Xinj iang patients with lupus nephritis

Objective To investigate urinary levels of monocyte chemoattractant protein 1（MCP-1）in Xin-jiang patients with lupus nephritis（LN）,and analyze the relationship of MCP-1 with 24-hour proteinuria and 24-hour urinary albumin-to-creatinine ratio（UACR）in active lupus nephritis.Methods A cross-sec-tional cohort analysis was performed.Urinary MCP-1 levels of 33 active lupus nephritis patients and 35 in-active lupus nephritis were measured by ELISA.Results Urinary MCP-1 levels of active lupus nephritis patients were significantly higher than that of inactive lupus nephritis 468.0（205-1 990）pg/mg Cr vs 131.5 （69-734）pg/mg Cr,P=0.000）.The mean age of active lupus nephritis was younger than that of inactive lupus nephritis（25.9 ± 3.7 vs 29.7 ± 3.5,P 〈 0.05）and the rate of positive anti-dsDNA antibody was higher in active lupus nephritis （P 〈 0.05）.However,there was no difference in gender and ethnicity be-tween the two groups （P 〉 0.05）.Urinary MCP-1 was strongly correlated with 24-hour proteinuria and 24-hour UACR （r= 0.916,P=0.000 ;r=0.936,P=0.000）.Conclusion Urinary MCP-1 concentration is a good biomarker for the j udgment of lupus nephritis flare and activity.Providing the Longitudinal stud-ies are warranted.