江苏省部分农村地区戊型肝炎血清流行病学研究

目的调查江苏省部分农村地区一般人群戊型肝炎的感染情况以及流行特征,为防治工作提供依据。方法利用分层整群抽样的方法,按不同的地区抽取若干个行政村的4139名自然人群,采用酶联免疫吸附试验(ELISA)检测该人群中HEV-IgG,HEV-IgM抗体水平。结果在调查的4139名自然人群中,抗HEV-IgG和抗HEV-IgM平均阳性率分别为52.0%和2.5%,男性和女性间的抗HEV-IgG和抗HEV-IgM阳性率差异有统计学意义,男性抗HEV-IgG阳性率(56.1%)高于女性(49.0%),而女性抗HEV-IgM阳性率(3.0%)高于男性(1.8%);同时戊肝感染可见于各个年龄段,但流行分布不平衡,差异有统计学意义,随着年龄的增长感染率呈上升的趋势。结论江苏省部分农村地区人群戊型肝炎病毒感染率明显高于国内已报道其他地区,各个年龄组均有感染。为降低感染率,探讨针对性的防治措施对策已刻不容缓。

Seroepidemiological Study on Hepatitis E Virus Infection in Rural General Population in Jiangsu Province

Objective To investigate the seroprevalence,epidemiological characteristics of hepatitis E virus(HEV) infection in an rural area of Jiangsu province. Methods Stratified-cluster sampling was carried out in different areas,4 139 persons were surveyed.Anti-HEV IgG and IgM were tested by commercial ELISA kits. Results The total anti-HEV IgG and IgM prevalence were 52.0% and 2.5% respectively in the general population. There were statistically significant differences in the seropositivity rates of anti-HEV IgG and IgM between male and female.The seropositivity rate of anti-HEV IgG in male(56.1%)is higher than that in female(49.0%),while the seropositivity rates of anti-HEV IgM in female (3.0%)is higher than that in male(1.8%). The antibodies increased with advancing age. Conclusion The prevalence of hepatitis E virus infection in those districts was higher than any other reported districts in China. HEV infection was found in every age, and increased with age, so there was no time to delay to take measures against prevalence of hepatitis E virus infection.