| 胃癌中P16基因启动子区甲基化检测的临床意义 |
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| 引用本文： | 李青,赵丽珍,王永福,郭春林,曹虹然,白雪峰.胃癌中P16基因启动子区甲基化检测的临床意义[J].内蒙古医学院学报,2007,29(1):33-36. |
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| 作者姓名： | 李青 赵丽珍 王永福 郭春林 曹虹然 白雪峰 |
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| 作者单位： | 包头医学院第一附属医院,基因诊断中心,内蒙古,包头,014010 |
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| 摘 要： | 目的：探讨P16基因启动子区域甲基化在胃癌发生和发展过程中的临床意义。方法：采用甲基化特异性PCR（MSP）对37例胃癌病人手术切除肿瘤组织及其癌旁组织P16基因启动子区域甲基化状态进行检测。结果：P16基因在手术切除的29．7％的胃癌组织和2．7％的癌旁组织发生了甲基化，且与年龄、性别、淋巴结转移以及分化程度等临床病理指标无相关性。结论：P16基因启动子区甲基化可能是肿瘤特异性的（P〈0．05），可作为胃癌早期诊断的分子标记物。
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| 关 键 词： | 胃癌 P16基因 甲基化 |
| 文章编号： | 1004-2113（2007）01-0033-04 |
| 收稿时间： | 2006-11-10 |
| 修稿时间： | 2007-01-10 |
CLINICAL SIGNIFICANCE OF PROMOTER METHYLATION OF P16 GENE IN GASTRIC CANCER |
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| LI Qing, ZHAO Li -zhen, WANG Yong- fu,et al..CLINICAL SIGNIFICANCE OF PROMOTER METHYLATION OF P16 GENE IN GASTRIC CANCER[J].Acta Academiae Medicinae Neimongol,2007,29(1):33-36. |
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| Authors: | LI Qing ZHAO Li -zhen WANG Yong- fu |
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| Institution: | Gene Diagnosis Center, First Affiliated Hospital, Baotou Medical College, Baotou 014010 China |
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| Abstract: | Objective:To investigate the clinical significance of promoter methylation of P16 gene in gastric cancer.Methods: The methylation status of P16 on surgically removed tumour tissues were examined by methylation-specific polymerase chain reaction(MSP) in 37 cases with gastric cancer.Results: Among samples obtained from patients with gastric cancer,methylation was observed in both the cancerous and paracancerous tissues with 29.7% and 2.7% for P16 respectively.No significant correlation between methylation status of P16 and clinical pathological characteristic was observed.Conclusion: Methylation of P16 gene is likely to be cancer specific(P<0.05),and may be utilized as a molecular diagnostic marker of gastric cancer in its early stage. |
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| Keywords: | gastric cancer P16 gene methylation |
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