输血传递病毒与肝炎相关关系的探讨

目的：研究输血传递病毒（TTV）在不同类型肝病患者中的感染情况及非甲－庚型（NA－G）肝炎中TTV是否为肝炎的致病因子。方法：采用nest-PCR技术对临床上129例肝病患者及反复输血的血液病患者血清检测了TTV－DNA。ELISA法检测血清抗HAV－IgM,HBV-M，抗HCV－IgM，抗HCV－IgM及血清ALT水平。结果：129例血清中TTV检出率为19．38％（25－129）。45例NA－G型肝炎患者中检出率为42．22％（19／45），其中急性肝炎9例，慢性肝炎9例，肝硬化1例，肿功均有程度不同的损害。结论：TTV感染是部分NA－G型肝炎患者的致病因子，可导致慢性化。除输血传播外尚有肠道传播的可能性。

EXPLORATION OF THE CORRELATION BETWEEN TT VIRUS AND HEPATITIS

Objective:To explore the infection circumstance of TT virus (TTV) in different hepatitis patients and whether TTV is the pathogenic factor to non-A-G hepatitis.Methods:Nest-PCR technology was adopted to detect TTV-DNA in sera of 129 liver patients and blood disease patients whose diseases had been caused by repeated transfusion.Immunoabsorbtion assay was used to detect anti-HAV-IgM,HBV-M,anti-HCV-IgM,anti-HEV-IgG,anti-HGV-IgM and ALT level in sera.Results:The detection rate of TTV DNA in 129 cases was 1938%(25/129) and it was 4222%(19/45) in 45 non-A-G hepatitis patients.Among these 45 patients,there were 9 acute hepatitis,9 chronic hepatitis,1 cirrhosis and liver functions were all injured.Conclusion:TTV infection is the pathogenic factor to part of non-A-G hepatitis and it can lead to the disease chronic.Besides transfusion,it is possible that TT virus spreads through intestines.