HLA—DQA1等位基因与儿童过敏性紫癜的相关研究

目的：研究过敏性紫癜（AP）的发病机理是否有免疫遗传因素的参与。方法：采用聚合酶链反应－序列特异性引物分型技术（PCR－SSP）对70例内蒙古地区的儿童AP病人进行了HLA－DQAl等位基因型别分析，并与90例正常儿童进行比较。结果：发现病人HLA－DQAl＊0301等位基因频率较正常对照组明显升高，二者的频率分别为27．9％和10．0％，经统计学检验差异有显著性（p＜0．01，RR＝5．56，EF＝0．45）；AP病人HLA－DQAl*0302等位基因频率较正常对照组明显降低，二者的频率分别为6．4％和17．2％，经统计学检验差异有显著性（p＜0．01，RR＝0．28，EF＝0．26）。结论：HLA－DQAl*0301等位基因可能是AP易感基因；HLA－DQAl*0302等位基因则可能为保护基因。

RELATION BETWEEN HLA--DQA1 ALLELE AND JUVENILEPATIENTS WITH ANAPHYLACTOID PURPURA

Objective:To investigate the possible involvement of hereditary factors in the pathogenesis of anaphylactoid purpura(AP). Methods:70 juvenile patients with AP and 90 normal children in Inner Mongolia region were tested for HLA-DQA1 allelic types analysis by PCR-SSP technique. Results:HLA-DQA1*0301 allele frequency was significantly higher in patients with AP than the control group,the frequencies were 27.9% and 10.0% respectively, and the difference had statistical significance( P <0.01,RR=0.26,EF=0.45);HLA-DQA1*0302 allele frequency was greatly lower in patients with AP than the control group,the frequencies were 6.4% and 17.2% respectively,and the difference had statistical significance( P <0.01,RR=0.28,EF=0.26). Conclusion:HLA-DQA1*0301 allele and HLA-DQA1*0302 allele maybe were the susceptible gene and the protective gene of AP respectively.