自分泌运动因子在胃癌中表达及其意义的研究

目的:研究自分泌运动因子(Autotaxin,ATX)在胃癌中的表达及其对肿瘤浸润转移的作用。方法:利用免疫组化技术研究ATX在73例胃癌手术切除标本及50例正常人胃黏膜组织标本之间的差异。结果:ATX在正常胃黏膜组织、胃癌组织、癌旁组织均有表达且有显著差异,癌旁组织与正常组织表达差异不明显。ATX表达与胃癌病人的性别、年龄、位置、大小无关,而与胃癌的组织学类型、分化程度、浸润深度、转移及TNM分期有关。肿瘤组织分化程度差,浸润较深,淋巴结转移,ⅢⅣ肿瘤的AT X表达明显高于组织分化程度较好,浸润较浅,无淋巴结转移,ⅠⅡ期肿瘤。结论:ATX高表达在胃癌浸润转移中有重要意义。

SIGNIFICANCE OF THE AUTOTAXIN EXPRESSION IN GASTRIC CANCER

Objective:study the expression of Autotaxin in gastric cancer and ATX’s significance on tumor invasion and transformation.Methods:We investigated the expression of the ATX by immunohistochemically in 73 gastric cancers and in 50 normal gastric mucosa,as well as analyzed the correlation between the expression of ATX and clinicopathological features.Results:ATX were expressed in normal gastric mucosa tissue,gastric tumor tissue and adjacent tissue.ATX were expressed highly in tumor tissue and lowly in normal and adjacent tissue.ATX was expressed highly in normal and adjacent tumor tissue,but lowly in gastric tumor tissue.ATX expression has correlation with Histological type,Grade of Differentiation,intramural invasion and transformation,but has no correlation with patients’ gender,age,location,and size of tumor.Tumor tissue with poor differentiation degree,deep invasion and a lymph node metastasis,TNM stage ⅢⅣ expressed in ATX were obviously higher than good differentiation degree,shallow invasion,without lymph node metastasis and TNM stage ⅠⅡ.Conclusion:High expression of ATX had important meaning in gastric tumor invasion transformation.