| 洛伐他汀对喉鳞状细胞癌细胞系Hep-2细胞增殖和凋亡的影响 |
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| 引用本文： | 屠建棋,高文明,窦姗姗,徐旭东.洛伐他汀对喉鳞状细胞癌细胞系Hep-2细胞增殖和凋亡的影响[J].济宁医学院学报,2013(5):317-319. |
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| 作者姓名： | 屠建棋 高文明 窦姗姗 徐旭东 |
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| 作者单位： | 济宁医学院基础学院,山东济宁272067 |
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| 摘 要： | 目的探讨阿伐他汀对喉鳞状细胞癌（LSCC）细胞系Hep-2细胞增殖和凋亡的影响。方法给予体外培养Hep-2细胞阿伐他汀处理，MTT法检测细胞活力，流式细胞仪检测细胞凋亡率，并分析超氧化物生成情况。结果阿伐他汀降低了Hep-2细胞活力，引起了Hep-2细胞凋亡，超氧化物水平升高。结论阿伐他汀对LSCC具有潜在的治疗作用。
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| 关 键 词： | 喉鳞状细胞癌 Hep-2 阿伐他汀 超氧化物 凋亡 |
Effects of lovastatin on the proliferation and apoptosis of Hep-2 cells in vitro |
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| Institution: | TU Jian-qi , GAO Wen-ruing, DOU Shan-shan , et al (Academy of Basic Medicine. Jining Medical University,Jining 272067,China) |
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| Abstract: | Objective To investigate the effects of lovastatin on the proliferation and apoptosis of Hep-2 cells in vitro. Methods Hep-2 cells were treated with lovastatin. Cell viability was measured by MTT assay. The apoptosis was detected by flow cytometry. And reactive oxygen species（ROS）production were analyzed. Results Lovastatin induced the decrease of cell viability in Hep-2 cells. The apoptotic rate of Hep-2 cells and the production of ROS in- creased after lovastatin treatment. Conclusion Lovastatin could be used potentially for the treatment of laryngeal squamous cell carcinoma. |
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| Keywords: | Laryngeal squamous cell carcinoma Hep-2 Lovastatin Reactive oxygen species Apoptosis |
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