无创正压通气对慢性阻塞性肺疾病急性加重期的治疗作用

目的探讨无创正压通气在慢性阻塞性肺疾病（COPD）急性加重期的治疗效果。方法选择COPD急性加重期的患者55例，随机分成两组。常规组：接受常规治疗，共25例。NPPV组：共30例，在接受常规治疗的基础上给予无创正压通气。观察患者治疗前和治疗后24h、3d的生命体征和血气分析等指标，以及两组患者的插管率。结果NPPV组患者治疗24h及3d后心率、呼吸明显好转，血气分析指标显著改善，且插管率明显降低，治疗前后差异明显（P〈0．05）。结论NPPV用于治疗COPD急性加重期疗效肯定，可缓解呼吸疲劳，改善缺氧和二氧化碳潴留，还可以减少气管插管率，是值得推广的治疗方法。

The investigation of non-invasive positive pressure ventilation in the treatment of acute exacerbation of COPD

Objective To investigate treatment effect of non-invasive positive pressure ventilation in acute ex- acerbation of COPD. Methods In 55 cases of patients with acute exacerbation of COPD,all patients were randomly divided into two groups： the control group included 25 cases who received conventional treatment and NPPV group included 30 cases who were given the noninvasive positive pressure ventilation when receiving routine treatment. At 24 hours and 3 days of vital signs blood gas analysis and other indicators were measured before and after treat- ment,and two groups patients were observed with intubation rate. Results In NPPV group,after patients were treated for 24 hours and 3 days the heart rate and respiration were improved. Blood gas analysis index improved significantly, and the intubation rate decreased significantly before and after the treatment（P〈0.05）. Conclusion NPPV is used for acute exacerbations of COPD and has an affirmative effect, which can alleviate respiratory fa- tigue,improve hypoxia and carbon dioxide retention, but also reduce the rate of endotracheal intubation. The treat- ment method is worth promoting.