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转化生长因子β1与哮喘的相关性及川芎嗪治疗哮喘的研究进展
引用本文:袁晓梅,郭悦鹏.转化生长因子β1与哮喘的相关性及川芎嗪治疗哮喘的研究进展[J].新乡医学院学报,2006,23(2):207-209.
作者姓名:袁晓梅  郭悦鹏
作者单位:新乡医学院一附院呼吸内科,河南,卫辉,453100
摘    要:目的了解转化生长因子-β1(TGF-β1)与哮喘的相关性及川芎嗪治疗哮喘的研究现状。方法应用现代信息技术,通过互联网等,查阅近年来国内外相关资料并进行分析、整理、总结,对TGF-β的生物学特征、TGF-β1与哮喘发病机制的相关性、川芎嗪对哮喘的治疗及其与TGF-β1的关系进行综述。结果TGF-β1在哮喘发病中起到复杂的生物调节作用,动物实验显示,川芎嗪治疗哮喘有效,而且部分是通过抑制TGF-β1的表达起作用。结论深入研究TGF-β1、哮喘及川芎嗪之间的相关性,会为哮喘的临床分级和治疗提供新的思路。

关 键 词:转化生长因子β1  哮喘  川芎嗪
文章编号:1004-7239(2006)02-0207-03
收稿时间:2006-01-15
修稿时间:2006-01-15

Correlation of transforming growth factorβ1 and asthma and advances on treatment of ligustrazine on asthma
YUAN Xiao-mei,GUO Yue-peng.Correlation of transforming growth factorβ1 and asthma and advances on treatment of ligustrazine on asthma[J].Journal of Xinxiang Medical College,2006,23(2):207-209.
Authors:YUAN Xiao-mei  GUO Yue-peng
Institution:Department of Respiratory, the First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China
Abstract:Objective To elucidate correlation of transforming growth factor β1(TGF-β1)and asthma and advances on treatment of ligustrazine on asthma.Methods By modern information technology such as Internet,Domestic and foreign related literatures were analyzed,summarized.The biological characteristic of TGF-β1,correlation of TGF-β1 with pathogenesis of asthma and treatment of ligustrazine on asthma and relation of ligustrazine and TGF-β1 were reviewed.Results TGF-β1 played a very implicated biological regulation on development of asthama,Animal experiments indicated that ligustrazine was effective in treatment of asthma,moreover,in part exerted role by inhibiting expression of TGF-β1.Conclusion Thorough study of TGF-β1 and correlation of asthma and ligustrazine will provide a new perspective for clinical grading and treatment of asthma.
Keywords:transforming growth factor-β1  asthma  ligustrazine
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