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| 心肌缺血预适应对初次急性心肌梗死患者临床及近期预后的影响 | |
| 引用本文： | 李明琰,滕清雷,高红艳.心肌缺血预适应对初次急性心肌梗死患者临床及近期预后的影响[J].新乡医学院学报,2006,23(1):66-68. |
| 作者姓名： | 李明琰 滕清雷 高红艳 |
| 作者单位： | 1. 洛阳市中心医院干部内科,河南,洛阳,471000 2. 新乡医学院三附院,河南,新乡,453003 3. 新疆维吾尔自治区急救中心,新疆,维吾尔,830004 |
| 摘 要： | 目的评价急性心肌梗死(AMI)发病前48h内的心绞痛发作对初次AMI临床及近期预后的影响。方法138例均为初次AMI患者,按发病前48h内有无心绞痛发作,分为缺血预适应(IP)组(n=54)和非缺血预适应(NIP)组(n=84),对比两组心肌酶峰值、恶性心律失常、心源性休克及院内死亡率。结果IP组临床及近期预后较好,表现为心肌梗死范围较小(P<0.05),心肌酶峰值较低(P<0.05),近期住院期间严重心律失常、心源性休克、明显心力衰竭、心源性病死率均低于NIP组(P<0.05)。结论初次AMI前48h内心绞痛的发作对心肌有一定的保护作用,其机理可能与心肌缺血预适应有关。 |
| 关 键 词： | 缺血预适应 急性心肌梗死 心绞痛 |
| 文章编号： | 1004-7239（2006）01-0066-03 |
| 收稿时间： | 2005-02-21 |
| 修稿时间： | 2005-02-21 |
Effects of myocardial ischemic preconditioning on first acute myocardial infarction and short-term prognosis |
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| LI Ming-yan,TENG Qing-lei,GAO Hong-yan.Effects of myocardial ischemic preconditioning on first acute myocardial infarction and short-term prognosis[J].Journal of Xinxiang Medical College,2006,23(1):66-68. | |
| Authors: | LI Ming-yan TENG Qing-lei GAO Hong-yan |
| Institution: | 1. Department of Internal Medicine, Luoyang Central Hospital, Luoyang 471000, China ;2. the Third Affiliated Hospital,Xinxiang Medical College, Xinxiang 453003, China ; 3. Department of Emergency Center, the Xinjiang Uygur Autonomous Region, Urumqi 830004, China |
| Abstract: | Objective To evaluate effects of angina pectoris attack on first acute myocardial infarction(AMI) and short-term prognosis within 48 h before AMI.Methods According to whether angina pectoris occurred or not within 48 h before AMI,138 patients were divided into ischemic preconditioning(IP) group(54 cases) and non-ischemic preconditioning(NIP) group (84 cases).Peak value of myocardial enzyme,malignant arrhythmia,cardiogenic shock and death rate in hospital were compared in two groups.Results The clinical features and short-term prognosis of group IP were better than that of group NIP,which was by demonstratied following facts:size of myocardial infarction was smaller (P<0.05),the peak value of myocardial enzyme was lower(P<0.05),incidence of malignant arrhythmia,cardiogenic shock ,dominant heart failure,cardiogenic mortality were lower in group IP than those in group NIP(P<0.05).Conclusion Angina pectoris attack within 48 h before first AMI passesses some to protective effect for myocardium.Its mechanism may be related to myocardial IP. |
| Keywords: | ischemic preconditioning acute myocardial infarction angina pectoris |
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