布地奈德粉吸入剂与多索茶碱联合治疗支气管哮喘68例

目的观察布地奈德粉吸入剂与多索茶碱联合治疗中、重度支气管哮喘的效果。方法68例中、重度支气管哮喘发作期患者,使用布地奈德粉吸入剂200~400μg.d-1,每日2次吸入,并用多索茶碱注射液200 mg加入生理盐水100 ml中,每日2次,静脉滴注,治疗1周。观察治疗前后哮喘症状、体征,测定最大呼气峰流速(PEF)及PEF占预计值百分比(PEF%)变化。结果治疗1周,临床控制17例,显效21例,好转24例,总有效率91.17%。治疗前PEF为2.80±1.04 L.s-1、PEF%为(60.42±13.15)%,治疗后PEF为4.00±1.10 L.s-1、PEF%为(81.53±14.25)%,治疗前后比较有显著差异(P<0.001)。不良反应发生率2.94%。结论联合布地奈德粉吸入剂与多索茶碱注射液治疗支气管哮喘疗效显著。

Combination budesonide powder inhalation with doxofylline injection for 68 cases of bronchial asthma

Objective To observe the effect of budesonide powder inhalation combined with doxofylline injection for patients with bronchial asthma.Methods 68 cases of moderate or serious bronchial asthma were treated for a week with budesonide powder inhalation 200～400 μg·d-1,twice a day,and combined with intravenous infusion of 200 mg of doxofylline injection which was added to 100 ml of saline,twice a day.All patients were treated for a week.The symptoms and signs of asthma were observed pre-and post-treatment,and the rate of peak expiratory flow(PEF) and PEF% were measured.Results For one week's treatment,clinical control was achieved in 17 cases,excellence was 21 cases,and improvement in 24 cases.Total effective rate was 91.17%.The rate of PEF and PEF% were 2.80±1.04 L·s-1,(60.42±13.15)% pre-treatment,and 4.00±1.10 L·s-1,(81.53±14.25)% post-treatment respectively.There were significant different of the PEF and PEF% pre-and post-treatment(P<0.001).The incidence rate of adverse effect was 2.94%.Conclusion The effect of budesonide powder inhalation combined with doxofylline injection for patients with bronchial asthma is obvious.