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丁咯地尔与前列腺素E1联合治疗急性脑梗死的临床价值
引用本文:袁彬.丁咯地尔与前列腺素E1联合治疗急性脑梗死的临床价值[J].新乡医学院学报,2008,25(4):379-381.
作者姓名:袁彬
作者单位:新乡医学院第一附属医院神经内科,河南,卫辉,453100
摘    要:目的探讨丁咯地尔与前列腺素E1联合治疗急性脑梗死的临床价值。方法88例急性脑梗死患者分为观察组和对照组,对照组给予右旋糖苷加川芎嗪静脉滴注,观察组在对照组治疗基础上加用盐酸丁咯地尔氯化钠注射液和前列腺素E1静脉滴注,均治疗14d。随访3个月,检测血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平,作临床神经功能缺损程度评分判定疗效。结果观察组和对照组治疗后血清hs-CRP、TNF-α含量均较治疗前显著降低(P<0.05),观察组血清hs-CRP、TNF-α降低程度明显高于对照组(P<0.05)。观察组的显效率和总有效率均明显高于对照组(P<0.05)。结论丁咯地尔与前列腺素E1联合对控制急性脑梗死具有良好疗效。

关 键 词:丁咯地尔  前列腺素E1  脑梗死  C反应蛋白  肿瘤坏死因子-α

Curative effect of buflomedil combine with prostaglandin E1 for treating acute cerebral infarction
YUAN Bin.Curative effect of buflomedil combine with prostaglandin E1 for treating acute cerebral infarction[J].Journal of Xinxiang Medical College,2008,25(4):379-381.
Authors:YUAN Bin
Institution:YUAN Bin ( Department of Neurology,the First Affiliated Hospital of Xinxing Medical College, Weihui 453100, China )
Abstract:Objective To observe curative effect of buflomedil combined with prostaglandin E1 for treating acute cerebral infarction. Methods Eighty-eight patients with acute cerebral infarction were divided into two groups:control group and experimental group. Patients in control group were given dextran combining with ligustrazine by intravenous drip, Basing on this, the experimental group were given buflomedil sodium chloride injection and prostaglandin E1 by intravenous drip. They were all treated for 14 days and followed up for 3 months. High-sensitive C-reactive protein and tumor necrosis factor-α were detected. And the curative effect was assessed by score of clinical neurologic impairment. Results The content of High-sensitive C-reactive protein and tumor necrosis factor-α in two groups post-treatment was obvious lower than pre-treatment( P 〈 0.05 ). The declined degree of high-sensitive C-reactive protein and tumor necrosis factor-α in experimental group was obvious higher than that in control group( P 〈 0.05 ). The excellence rate and total effective rate of experimental group were higher than that of control group (P 〈 0.05 ). Conclusion Buflomedil injection combine with prostaglandin E1 injection are effective medicine for treating acute cerebral infarction.
Keywords:buflomedil  prostaglandin E1  cerebral infarction  C-reactive protein  tumor necrosis factor-α
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