首页 | 本学科首页   官方微博 | 高级检索  
检索        

参麦注射液对家兔缺血再灌注损伤肠微循环的保护作用
引用本文:焦勇钢,孙银平.参麦注射液对家兔缺血再灌注损伤肠微循环的保护作用[J].新乡医学院学报,2005,22(3):213-215.
作者姓名:焦勇钢  孙银平
作者单位:新乡医学院病理生理学教研室,河南,新乡,453003
摘    要:目的研究参麦注射液(SM)对家兔缺血再灌注(IR)损伤时肠微循环的保护作用。方法将18只家兔随机分为对照组、单纯缺血再灌注(IR)组、缺血再灌注+参麦(IR+SM)组,各6只。用医学图像分析系统在缺血30min、缺血再灌注60min时,分别记录肠系膜微动静脉管径、血流速度和管袢数。结果缺血30min时IR组、IR+SM组分别与对照组比较,微动静脉管径缩小,血流速度减慢,管袢数减少(P<0.01);再灌注60min时IR+SM组与IR组比较,微动静脉扩张显著,血流速度加快,管袢数增加(P<0.01);再灌注60min时IR+SM组与对照组比较,各项指标无显著差异(P>0.05),各项指标基本恢复正常。结论家兔缺血再灌注时存在微循环障碍,而SM具有改善缺血再灌注损伤时微循环障碍的作用。

关 键 词:家兔  缺血再灌注  微循环  参麦注射液
文章编号:1004-7239(2005)03-0213-03

The protective effect of Shen-Mai injection on microcirculation of mesentery in rabbits with ischemia and reperfusion
JIAO Yong-gang,Sun Yin-ping.The protective effect of Shen-Mai injection on microcirculation of mesentery in rabbits with ischemia and reperfusion[J].Journal of Xinxiang Medical College,2005,22(3):213-215.
Authors:JIAO Yong-gang  Sun Yin-ping
Abstract:Objective To study the protective effect of Shen-Mai (SM) injection on microcirculation of ischemia-reperfusion(IR) injury in mesentery of rabbit and discuss it the possible mechanism.Methods Eighteen rabbits were randomly divided into control group,simple IR group,IR plus Shen-Mai administration group.The diameters,the blood flow velocity of microarteriole and microvenule,the number of capillary vessel were studied by image analyzer at the point of 30mins of ischemia and 60 mins of reperfusion respectively.Results At the point of 30mins of ischemia,compare with control group,the diameters of microvascular,the blood flow velocity and the number of capillary vessel decreased remarkedly in IR group and IR SM group (P<0.01).At the point of 60 mins of reperfusion,if compared with IR group,the five indexes in IR SM group increased significally (P<0.01);But at the same point,there were no significant difference if the five indexes in the IR SM group were campared with those in control group(P>0.05).Conclusion There are failure of microcirculation during IR ,but SM may ameliorate microcirculation.
Keywords:rabbit  ischemia reperfusion  microcirculation  Shen-Mai injection
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号