黄芪注射液对老年冠心病患者血清中白细胞介素-6和肿瘤坏死因子-α含量的影响

目的探讨黄芪注射液对老年冠心病(CHD)患者早期血清中白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量的影响。方法96例老年CHD患者分为黄芪治疗组(54例)和常规治疗组(42例),常规治疗组仅给予常规治疗,黄芪治疗组在常规治疗的基础上给予黄芪注射液20 mL,加入生理盐水250 mL中静脉滴注,每日1次;疗程14 d。分别采用酶联免疫吸附测定法、放射免疫法测定治疗前后血清IL-6、TNF-α的含量,并对治疗后2组临床疗效进行比较。另选正常健康者30例为对照组。结果黄芪治疗组与常规治疗组治疗前血清中IL-6、TNF-α的含量水平比较无显著差异(P>0.05),但较对照组明显升高(P<0.01);黄芪治疗组与常规治疗组治疗后较治疗前血清中IL-6、TNF-α含量均显著降低(P<0.05),但黄芪治疗组较常规治疗组降低更显著(P<0.05)。黄芪治疗组临床疗效优于常规治疗组(P<0.05)。结论黄芪注射液可明显降低老年CHD患者早期血清中IL-6、TNF-α含量,而且临床疗效好。

Effects of Astragalus mongholicus injection on serum interleukin-6 and tumor necrosis factor-a level in old patients with coronary heart diseases

Objeαive To explore the effeαs of Astragalus mongholicus injeαion on serum interleukin-6 （IL-6）and tumor necrosis faαor-α（TNF-α） level in old patients with coronary heart diseases （CHD）. Methods ninety-six patients with CHD were divided into Astragalus mongholicus treatment group （ n = 54） and conventional treatment group （ n = 42 ）. The patients in conventional treatment group were treated with conventional therapy, based on this, the patients in Astragalus mongholicus treatment group were treated with Astragalus mongholicus injeαion 20 mL and normal saline 250 mL by vein, one time a day, for 14 days. 30 healthy volunteers were supposed as control group. The serum IL-6 and TNF-α were deteαed with enzyme-linked immu- nosorbent assay and radioimmunoassay, the clinical curative effeα was compared between two groups. Results There was no significant difference in the serum IL-6,TNF-α level between Astragalus mongholicus treatment group and conventional treatment group before treatment（P 〉 0.05 ）, but the serum IL-6 and TNF-α level in these two groups were higher than these in control group （ P 〈 0.01 ）. The serum IL-6 and TNF-α level was lower posttreatment in Astragalus mongholicus treatment group and conventional treatment group（P 〈 0.05 ）. After treatment, the serum IL-6 and TNF-α level was lower in Astragalus mongholicus treatment group than these in conventional treatment group （ P 〈 0.05 ）. The clinical curative effeα was better in Astragalus mon- gholicus treatment group than this in conventional treatment group （ P 〈 0.05 ）. Conclusion Astragalus mongholicus injeαion can obviously decrease the serum IL-6 ,TNF-α level in patients with CHD, and can obtain good clinical curative effeαs.