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| 肺动脉高压血浆内皮素-1和一氧化氮水平变化及临床意义 | |
| 引用本文： | 周义乾,张素荣,李金兰.肺动脉高压血浆内皮素-1和一氧化氮水平变化及临床意义[J].新乡医学院学报,2009,26(2):164-166. |
| 作者姓名： | 周义乾 张素荣 李金兰 |
| 作者单位： | 1. 新乡医学院第一附属医院结核科,河南卫辉,453100 2. 新乡医学院第一附属医院心内科,河南卫辉,453100 3. 新乡医学院第一附属医院呼吸内科,河南卫辉,453100 |
| 摘 要： | 目的探讨肺动脉高压患者血浆内皮素-1(ET-1)和一氧化氮(NO)水平变化及临床意义。方法选择88例肺动脉高压患者(观察组)和30例健康体检者(对照组),抽取空腹静脉血4 mL分别测定ET-1和NO,并进行对照比较。结果观察组血浆ET-1水平为(108.04±21.11)ng.L-1,对照组为(52.52±16.00)ng.L-1,观察组显著高于对照组(P<0.01);观察组和对照组NO水平分别为(88.26±25.28)μmol.L-1和(128.16±38.36)μmol.L-1,观察组显著低于对照组(P<0.01);且ET-1和NO水平与病情程度呈明显相关(P<001)。结论肺动脉高压患者血浆ET-1水平显著增高,NO水平显著降低,且与病情程度呈明显相关性。 |
| 关 键 词： | 肺动脉高压 内皮素-1 一氧化氮 |
Changes of plasma endothlin-1 and nitric oxide in pulmonary hypertension |
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| ZHOU Yi-qian,ZHANG Su-rong,LI Jin-lan.Changes of plasma endothlin-1 and nitric oxide in pulmonary hypertension[J].Journal of Xinxiang Medical College,2009,26(2):164-166. | |
| Authors: | ZHOU Yi-qian ZHANG Su-rong LI Jin-lan |
| Institution: | ZHOU Yi-qian,ZHANG Su-rong,LI Jin-lan3(1.Department of Tuberculosis;the First Affiliated Hospital of Xinxiang Medical College;Weihui 453100;China;2.Department of Cardiovascular Medcine;the First Affiliated Hospital of Xinxiang Medical College;Weihui 453100;China;3.Department of Respiratory Medcine;the First Affiliated Hospital of Xinxiang Medical College;Weihui 453100;China) |
| Abstract: | Objective To investigate the variation of plasma Endothlin（ET^-1） and Nitric oxide（NO） in patients with pulmonary hypertension.Methods Concentrations of Endothlin 、Nitric oxide were determined in patients with pulmonary hypertension group（88 cases） and control group（30 cases）.Results Concentration of ET^-1 in observation group（108.04±21.11）ng·L^-1 was higher than that in control group（52.52±16.00）ng·L^-1（P〈0.01）,and NO concentration in observation group（88.26±25.28）μmol·L^-1 was lower than that in control group（128.16±38.36）μmol·L^-1（P〈0.01）.Conclusion The levels of ET^-1 in pulmonary hypertension patients are higher,while NO are lower.ET^-1 levels increase and NO levels decrease with severity of pulmonary hypertension. |
| Keywords: | pulmonary gypertension endothlin- nitric oxide |
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