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三氧化二砷抗肿瘤机制及其与放化疗敏感性的关系
引用本文:汤继英,陈萍.三氧化二砷抗肿瘤机制及其与放化疗敏感性的关系[J].新乡医学院学报,2007,24(4):422-425.
作者姓名:汤继英  陈萍
作者单位:郧阳医学院附属人民医院肿瘤中心,湖北,十堰,442000
摘    要:综述了国内外有关三氧化二砷抗肿瘤机制、三氧化二砷与放射治疗及化学治疗敏感性关系的文献,发现三氧化二砷抗肿瘤的机制主要为调整细胞周期分布、诱导细胞凋亡、阻断肿瘤细胞的亚致死性损伤的修复等,当其与放射治疗、化学治疗联合应用时具有增敏的作用。三氧化二砷的抗肿瘤的机制错综复杂;三氧化二砷具有放射治疗、化学治疗增敏作用,但作为它们的增敏剂在临床上应用还存在一定的距离。

关 键 词:三氧化二砷  肿瘤  作用机制  放射治疗  化学治疗
文章编号:1004-7239(2007)03-0422-04
收稿时间:2007-01-23
修稿时间:2007-01-23

The mechanism of anti-carcinoma by arsenic trioxide(ATO) and the relationship between ATO and radiosensitivity or chemosensitivity
TANG Ji-ying,CHEN Ping.The mechanism of anti-carcinoma by arsenic trioxide(ATO) and the relationship between ATO and radiosensitivity or chemosensitivity[J].Journal of Xinxiang Medical College,2007,24(4):422-425.
Authors:TANG Ji-ying  CHEN Ping
Abstract:To review the literature about the mechanism of anti-carcinoma by arsenic trioxide(ATO) and the relationship between ATO and radiosensitivity or chemosensitivity,found that the main mechanisms of anti-carcinoma by ATO were as follow:redistributing of cell cycle,inducing of apoptosis,inhibiting the repair of reversible DNA damage and so on.When combined with radiotherapy or chemotherapy,ATO can enhance the curative effect.The mechanism of anti-carcinoma by ATO is various;Although ATO has the role of sensitization,it has some distance for ATO to be used as sensitizer in clinic.
Keywords:arsenic trioxide  carcinoma  function mechanism  radiotherapy  chemotherapy
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