慢性阻塞性肺疾病继发真菌感染65例病原菌分布及耐药性分析

目的探讨慢性阻塞性肺疾病(COPD)继发真菌感染的病原菌分布及耐药情况。方法对65例COPD继发真菌感染患者的痰液进行真菌培养鉴定,并进行药物敏感性试验。结果65例COPD继发真菌感染的患者检测出白色念珠菌38例(58.46%),酵母样真菌10例(15.38%),光滑念珠菌9例(13.84%),克柔念珠菌4例(6.15%),热带念珠菌2例(3.07%),毛霉菌2例(3.07%)。药敏结果显示白色念珠菌对制霉菌素、两性霉素B、伊曲康唑和5-氟尿嘧啶敏感性较高,对益康唑和酮康唑敏感性较低。结论COPD患者继发肺部真菌感染多为白色念珠菌感染。临床治疗时应选择针对性强、抗菌谱窄的抗生素。

Distribution and drug resistance of pathogenic bacteria in sixty-five patients with chronic obstructive pulmonary diseases and secondary fungus infection

ObjectiveTo investigate the distribution and drug resistance of pathogenic bacteria in patients with chronic obstructive pulmonary diseases(COPD) and secondary fungus infection.MethodsThe sputamentums of sixty-five patients were performed with germiculture,and the drug sensitivity test was carried out.ResultsAmong 65 cases,blastomyces albicans in 38 cases(58.46%),fermentums in 10 cases(15.38%),smooth bacterium in 9 cases(13.84%),candida krusei in 4 cases(6.15%),candida tropicalis in 2 cases(3.07%),mold fungus in 2 cases(3.07%),were detected.The result of drug sensitivity test showed that blastomyces albicans was sensitive to anticandine,amphotericin B,itraconazole and 5-fluorouracil,but blastomyces albicans was insensitive to econazole and ketoconazole.ConclusionBlastomyces albicans is major pathogenic bacterium in patients with COPD and secondary fungus infection.The treatment should choose the direct and narrow-spectrum antibiotics.