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妊娠相关蛋白A及C-反应蛋白与代谢综合征的关系
引用本文:可海霞,贾银明,韩勤甫,王淑红,金培印,申娟,张海柱.妊娠相关蛋白A及C-反应蛋白与代谢综合征的关系[J].新乡医学院学报,2008,25(1):71-73.
作者姓名:可海霞  贾银明  韩勤甫  王淑红  金培印  申娟  张海柱
作者单位:安阳市人民医院心内科,河南,安阳,455000
摘    要:目的探讨妊娠相关蛋白A(PAPP-A)、C-反应蛋白(CRP)与代谢综合征(MS)的关系。方法采用双抗体夹心酶联免疫吸附实验检测50例MS患者和30例正常对照者的血清PAPP-A的水平;常规检测CRP、空腹血糖(FPG)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A-I(ApoA-I)、载脂蛋白B(ApoB)、ApoA-I/ApoB、血压(BP)、腰围(WC),并将PAPP-A的水平与CRP的水平及MS各特征参数作相关分析。结果观察组血清CRP、PAPP-A浓度较正常对照组增高(P<0.01);PAPP-A与CRP、WC、TG、TC、SBP、DBP呈正相关(r分别为0.422,0.396,0.296,0.564,0.289,均P<0.05),与LDL-C、ApoA-I/ApoB呈负相关(r=-0.450,r=-0.355,P<0.05)。结论PAPP-A、CRP在MS的病理生理机制中发挥重要作用,是心血管疾病的预测因子。

关 键 词:代谢综合征  C反应蛋白  妊娠相关蛋白A
文章编号:1004-7239(2008)01-0071-03
收稿时间:2007-08-08
修稿时间:2007年8月8日

Relationship between pregnancy-associated Plasma Protein A,C-reactive Protein and metabolic syndrome
KE Hai-xia,JIA Yin-ming, HAN Qin-fu,et al.Relationship between pregnancy-associated Plasma Protein A,C-reactive Protein and metabolic syndrome[J].Journal of Xinxiang Medical College,2008,25(1):71-73.
Authors:KE Hai-xia  JIA Yin-ming  HAN Qin-fu  
Institution:KE Hai-xia,JIA Yin-ming, HAN Qin-fu,et al (Department of Cardiovasculary,Anyang People's Hospital,455000)
Abstract:Objective To investigate the relationship between pregnancy-associated plasma protein-A(PAPP-A),C-reactiveprotein(CRP) and metabolic syndrome(MS).Methods The level of serum PAPP-A in fifty patients with MS and 30 healthy subjects were detected by Enzyme-linked immunosorbent assay(ELISA).Serum CRP,fasting plasma glucose(FPG),blood pressure(BP),waist circumference(WC),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) were detected routinely.Correlation analysis between PAPP-A,CRP and MS was studied.Results The serum levels of PAPP-A and CRP were significantly higher in observation group than these in control group(P<0.01).Highly positive correlation between the serum concentration of PAPP-A and CRP,WC,BP,TC,TG were observed(r=0.422,0.396,0.296,0.564,0.289,P<0.05),and significant negative correlation between serum level of PAPP-A and LDL-C,ApoA-I/ApoB were found(r=-0.450,r=-0.355,P<0.05).Conclusion PAPP-A and CRP play an important role in the pathogenesis of MS,and both PAPP-A and CRP are predict risk factors of cardiovascular disease.
Keywords:metabolic syndrome  C-reactive protein  pregnancyassociated plasma protein A
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