泮托拉唑预防急性心肌梗死后应激性溃疡出血

目的观察泮托拉唑对急性心肌梗死后应激性溃疡出血的预防作用。方法223例急性心肌梗死患者分为泮托拉唑组(121例)和对照组(102例),对照组常规应用抗血小板聚集、溶栓、抗凝等治疗,泮托拉唑组在常规治疗基础上应用泮托拉唑;观察2组患者肝、肾功能及应激性溃疡出血的发生率。结果泮托拉唑组发生应激性溃疡出血2例(1.7%),对照组发生应激性溃疡出血12例(11.9%)。泮托拉唑组应激性溃疡出血发生率明显低于对照组(P<0.05);2组治疗前后肝、肾功能差异无统计学意义(P>0.05)。结论泮托拉唑能有效预防急性心肌梗死后应激性溃疡出血。

Preventive effect of pantoprazole for the hemorrhage of stress ulcer in the patients with acute myocardial infraction

Objective To observe the preventive effect of pantoprazole for the hemorrhage of stress ulcer in the patients with acute myocardial infraction.Methods 223 cases of acute myocardial infraction were divided into pantoprazole group（n=121） who were treated with pantoprazole on the base of routine therapy and control group（n=102） who accepted only routine therapy such as platelet aggregation inhibitors,anti-coagulation,thrombolysis etc.The liver and renal function and the incidence of hemorrhage of stress ulcer were observed between two groups.Results The incidence of hemorrhage of stress ulcer in pantoprazole group（2 cases,1.7%） was signigicantly lower than control group（12 cases,11.9%）（P〈0.05）.There were no statistic difference of Liver function and renal function pre and post treatment between two groups.Conclusion Pantoprazole could effectively prevent the hemorrhage of stress ulcer in patients with acute myocardial infraction.