甲状腺癌多药耐药基因MRP、P-gp的表达及临床意义

目的　探讨多药耐药相关蛋白 (MRP)和P 糖蛋白 (P gp)在甲状腺癌中的表达及临床意义。方法　采用免疫组化SP法回顾性检测分析 80例甲状腺癌组织MRP和P gp表达状况。结果　MRP和P gp表达阳性率分别为 86 .3%、76 .3% ,二者有显著差异 (P <0 .0 5 ) ,两者在甲状腺癌各类型中表达较一致 ,乳头状癌和髓样癌表达阳性率无显著差异 (P >0 .0 5 ) ,滤泡癌中表达阳率明显低于乳头状癌和髓样癌 (P <0 .0 5 )。MRP与P gp共表达率为 76 .3% (6 1/ 80 ) ,具有相关性(P <0 .0 1)。结论　MRP和P gp在甲状腺癌中阳性率较高 ,提示甲状腺癌对化疗有一定多药耐药性。

Expression and clinical significance of multidrug resistance gene MRP and P-gp in thyroid carcinoma

Objective To investigate expression and clinical significance of multidrug resistance protein P-glycoprotein(P-gp)and multidrug resistance associated protein(MRP) in thyroid carcinoma.Method SP immunohistochemical technique was used to detect the expression of MRP and P- gp in 80 cases of thyroid carcinoma.Results The frequency of expression of MRP and P-gp in thyroid carcinoma was 86.3% and 76.3% respectively.The difference between them was statistically significant(P<0.05).The MRP and P-gp had coincident expression in various thyroid carcinoma,but there was no significant difference between papillary carcinoma and medullary carcinoma.The frequency of MRP and P-gp expression in pollicilar thyroid carcinoma was lower than that of papillary and medullar thyroid carcinoma(P>0.05).The coexpression of MRP and P-gp was 76.3%(61/80),positive correlation was observed between MRP and P-gp (P<0.01).Conclusion The high level expression of MRP and P-gp suggests multidrug resistance to the chemotherapeutic agents in thyroid carcinoma.