尿微量白蛋白和血清胱抑素C联合检测对评估2型糖尿病患者早期肾损伤的价值

目的探讨血清胱抑素C(Cys-C)和尿微量白蛋白(UMA)联合检测对评估2型糖尿病患者早期肾损伤的价值。方法 235例2型糖尿病患者按尿蛋白定性检测结果分为尿蛋白阳性组74例和尿蛋白阴性组161例,检测2组患者血清Cys-C、肌酐(SCr)及UMA水平。结果尿蛋白阳性组患者血清Cys-C、SCr和UMA水平显著高于尿蛋白阴性组(P<0.05或P<0.01)。2组患者血清Cys-C和UMA阳性率均显著高于SCr阳性率(P<0.01),尿蛋白阳性组患者血清Cys-C、UMA、SCr阳性率及Cys-C和UMA联合检测阳性率均显著高于尿蛋白阴性组(P<0.01),尿蛋白阴性组患者血清Cys-C和UMA联合检测阳性率显著高于单纯Cys-C或UMA检测阳性率(P<0.05)。结论联合检测血清Cys-C和UMA可提高诊断2型糖尿病早期肾损伤的敏感性。

Value of combined determination of urine microalbumin and serum cystatin C levels for evaluating early renal injury in patients with type 2 diabetes mellitus

Objective To explore the value of combined determination of urine microalbumin(UMA)and serum cystatin C(Cys-C)levels for evaluating early renal injury in patients with type 2 diabetes mellitus(T2DM).Methods A total of 235 patients with T2DM were divided into urine protein positive group(n=74)and urine protein negative group(n=161)according to the results of urine protein detection.The levels of serum Cys-C,serum creatinine(SCr)and UMA were determined in the two groups.Results The levels of Cys-C,SCr and UMA in urine protein positive group were significantly higher than those in urine protein negative group(P<0.05 or 0.01).The positive rates of serum Cys-C and UMA were significantly higher than those of SCr in the two groups(P<0.01),the positive rates of serum Cys-C,UMA,SCr,combined determination of Cys-C and UMA in urinary protein positive group were significantly higher than those in urine protein negative group(P<0.01);the positive rate of combined determination of Cys-C and UMA was significantly higher than that of single Cys-C or UMA detection in urine protein negative group(P<0.05).Conclusion Combined determination of serum Cys-C and UMA levels can increase the diagnosis sensitivity of early renal injury in patients with T2DM.