| 食管癌中抑癌基因PTEN的表达及临床意义 |
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| 引用本文： | 韩宇,曹青山,常廷民,王光辉,杨承汉.食管癌中抑癌基因PTEN的表达及临床意义[J].新乡医学院学报,2007,24(2):109-110. |
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| 作者姓名： | 韩宇 曹青山 常廷民 王光辉 杨承汉 |
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| 作者单位： | 新乡医学院第一附属医院消化内科,河南,卫辉,453100 |
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| 基金项目： | 河南省科技厅科技攻关项目 |
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| 摘 要： | 目的探讨抑癌基因PTEN在食管癌中的表达及临床意义。方法用免疫组织化学方法检测80例食管癌及其相应的手术远端正常食管组织中PTEN蛋白的表达水平。结果PTEN在食管鳞癌中的表达率明显低于癌旁正常食管黏膜组织(P<0.01),而且PTEN蛋白表达与肿瘤分化程度、浸润深度、淋巴结转移相关(P<0.01)。结论从蛋白水平证明PTEN基因表达缺失或突变在食管鳞癌的发生发展中可能起重要作用,PTEN蛋白表达的检测可作为临床治疗和判断预后的依据。
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| 关 键 词： | 食管鳞癌 抑癌基因 PTEN 免疫组织化学 |
| 文章编号： | 1004-7239（2007）02-0109-02 |
| 收稿时间： | 2006-10-29 |
| 修稿时间： | 2006-10-29 |
Expression and significance of PTEN in esophageal carcinoma |
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| HAN Yu, CAO Qing-shan, CHANG Ting-min,et al.Expression and significance of PTEN in esophageal carcinoma[J].Journal of Xinxiang Medical College,2007,24(2):109-110. |
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| Authors: | HAN Yu CAO Qing-shan CHANG Ting-min |
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| Institution: | Department of Digestion ,the First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China |
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| Abstract: | Objective To investigate expression and significance of tumor suppressor gene PTEN in esophageal carcinoma.Methods Expression of PTEN was examined by immunohistochemical SP method in 80 cases of esophageal carcinoma and normal esophageal tissues closely adjacent to carcinoma.Results The incidence of PTEN in esophageal carcinoma was obviously lower than that of normal esophageal tissue(P<0.01).The expression of PTEN was correlated with degree of differentiation of carcinoma,lymph node metastasis(P<0.01).Conclusion The loss or mutation of PTEN gene maybe play an important role in tumor genesis and progress of esophageal carcinoma.It is valuable for clinical treatment and judging prognosis to detect the expression of PTEN in esophageal carcinoma. |
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| Keywords: | PTEN |
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