脑出血早期患者出血量与血清白介素-6和肿瘤坏死因子-α的关系

目的观察白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)在脑出血早期患者血清中IL-6、TNF-α含量变化,探讨其对脑出血预后生活质量的影响。方法采用ELISA法、放射免疫法测定169例脑出血早期患者入院d2血清中IL-6、TNF-α水平,其中出血10~29ml组41例,30ml~49ml组93例,50~60ml组35例。设30例健康人作对照。同时对出院者进行神经功能缺损评分(NDS)评定,观察IL-6、TNF-α不同含量水平对脑出血预后生活质量的影响。结果与对照组比较,出血量10ml以上者血清中IL-6、TNF-α含量明显升高(P<0.05);30ml以上组较10ml以上组显著升高(P<0.05),但低于50ml以上组(P<0.05)。同等条件下脑出血患者早期血清中IL-6、TNF-α含量越高,NDS越下降(P<0.05,P<0.01)。结论脑出血患者早期血清中IL-6、TNF-α含量明显升高,出血量与其后的生活质量有关。

Relationship between the serum levels of IL-6,TNF-α level and bleeding amount after cerebral hemorrhage

Objective To observe the changes of the serum levels of IL-6,TNF-α in early cerebral hemorrhage (ECH) and study the effect of bleeding amount on prognostic quality of life.Methods The ELISA and RIA were respectively used for detection of IL-6 and TNF-α levels in 169 ECH patients,Who divided into 10～29 ml group (n=41), 30 ml～49 ml group (n=93), 50～60 ml group (n=35),acoding to bleeding amount, and 30 healthy subjects was as control (heath group,n=30).The neurological deficit scores(NDS) at the time of discharge was compared in patients with different amounts of bleeding.Results The serum IL-6 and TNF-α levels in of 10～29 ml group of bleeding amount were higher than in control group (P<0.05), the 30～49 ml group of bleeding amount were higher than in 10～29 ml group (P<0.05)while lower than that in 50～60 ml group( P<0.01). In same condition after cerebral hemorrhage.the higher of the serum IL-6 and TNF-α level, the lower of the NDS(P<0.05 and P<0.01 Respectively ).Conclusion There are usually elevated serum IL-6 and TNF-α levels in cerebral bleeding patients,and the bleeding amount is correlation with subsequently quality of life.