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更昔洛韦治疗儿童传染性单核细胞增多症35例
引用本文:闫红敏.更昔洛韦治疗儿童传染性单核细胞增多症35例[J].新乡医学院学报,2007,24(2):175-176.
作者姓名:闫红敏
作者单位:禹州市妇幼保健院儿科,河南,禹州,461600
摘    要:目的观察更昔洛韦治疗儿童传染性单核细胞增多症的临床疗效。方法70例传染性单核细胞增多症(IM)患儿随机分为对照组和治疗组,2组患儿在给予常规治疗的基础上,对照组30例给予利巴韦林10 mg.kg-1.d-1,加入10%葡萄糖注射液100-200 ml,静脉滴注;治疗组30例给予更昔洛韦10 mg.kg-1.d-1,加入10%葡萄糖注射液100-200 ml,静脉滴注;疗程均为7-10 d。结果治疗组总有效率(94.29%)明显高于对照组(68.57%,P<0.01);治疗组热程、咽峡炎改善、淋巴结开始缩小、肝脾明显缩小、平均住院时间、异型淋巴细胞恢复至<10%的时间均较对照组明显缩短(P<0.01或P<0.05);治疗组有2例粒细胞减少,1例血小板减少,停药1周后恢复正常。结论更昔洛韦治疗儿童传染性单核细胞增多症疗效好。

关 键 词:传染性单核细胞增多症  儿童  更昔洛韦
文章编号:1004-7239(2007)02-0175-02
收稿时间:2006-11-10
修稿时间:2006-11-10

Ganciclovir for 35 cases of infectious mononucleosis
YAN Hong-min.Ganciclovir for 35 cases of infectious mononucleosis[J].Journal of Xinxiang Medical College,2007,24(2):175-176.
Authors:YAN Hong-min
Abstract:Objective To observe the clinical curative effect of ganciclovir for the treatment of children with infectious mononucleosis.Methods Seventy cases of infectious mononucleosis were randomly divided into control group and treatment group.Besides conventional therapy,control group(n=35)were performed with 10 mg·kg-1·d-1 ribovirin plus 100~200 ml glucose injection by intravenous drip infusion,treatment group(n=35)were performed with 10 mg·kg-1·d-1 ganciclovir plus 100~200 ml glucose injection by intravenous drip infusion,the course of treatment was 7~10 days.Results The total effective rate of treatment group(94.29%) was significantly higher than control group(68.57%,P<0.01),the time of fever,angina,lymphaden growing downwards,liver and spleen growing downwards,average stay and atypical lymphocyte returning to under 10% of treatment group were obviously shortened than those of control group(P<0.01,P<0.05).Two cases of Granulocytopenia and one cases of thrombocytopenia in treatment group recovered normal after drug withdrawal.Conclusion Ganciclovir for children with infectious mononucleosis is effective.
Keywords:infectious mononucleosis  children  ganciclovir
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