瑞舒伐他汀对不稳定型心绞痛患者经皮冠状动脉介入术后心肌损伤的保护作用

目的探讨瑞舒伐他汀对不稳定型心绞痛(UAP)患者经皮冠状动脉介入(PCI)术后心肌损伤的保护作用。方法 98例行PCI术治疗的UAP患者分为观察组和对照组,每组49例。观察组患者在常规治疗基础上给予瑞舒伐他汀钙片治疗,对照组患者在常规治疗基础上给予阿托伐他汀钙片治疗,比较2组患者血清肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(c Tn I)、人心型脂肪酸结合蛋白(h-FABP)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(INF-γ)、白细胞介素-10(IL-10)及超敏C反应蛋白(hs-CRP)水平。结果 PCI术前2组患者血清CK-MB、c Tn I及h-FABP水平比较差异均无统计学意义(P>0.05)。对照组患者PCI术后血清CK-MB和c Tn I水平显著高于术前(P<0.05),但对照组患者PCI术前后血清h-FABP水平比较差异无统计学意义(P>0.05);观察组患者PCI术前后血清CK-MB、c Tn I及h-FABP水平比较差异均无统计学意义(P>0.05)。PCI术后观察组患者血清CK-MB和c Tn I水平显著低于对照组(P<0.05),但PCI术后2组患者血清h-FABP水平比较差异无统计学意义(P>0.05)。PCI术前2组患者血清TNF-α、INF-γ、IL-10及hs-CRP水平比较差异均无统计学意义(P>0.05)。2组患者PCI术后血清hs-CRP水平显著高于术前(P<0.05);对照组患者PCI术后血清IL-10水平显著高于术前(P<0.05);PCI术后观察组患者血清IL-10和hs-CRP水平显著低于对照组(P<0.05)。2组患者PCI术前后血清TNF-α和INF-γ水平均无显著变化(P>0.05)。结论瑞舒伐他汀能有效减轻UAP患者PCI术后炎症反应,对心肌损伤有保护作用。

Protective effect of rosuvastatin on myocardial injury after percutaneous coronary intervention in patients with unstable angina pectoris

Objective To explore the protective effect of rosuvastatin on myocardial injury after percntaneous coronary intervention （PCI） in patients with unstable angina pectoris （UAP）. Methods Ninety-eight patients with UAP underwent PCI were divided into observation group and control group, forty-nine patients in each group. The patients in observation group were treated with rosuvastatin calcium tablet, and the patients in control group were treated with atorvastatin calcium tablet on the basis of conventional therapy. The levels of creatine kinase-MB （CK-MB）, cardiac troponin I（ cTnI）, human fatty acid-binding protein （h-FABP） ,tumour necrosis factor-α （ TNF-α ） , interferon-γ（INF-γ） , interleukin-10 （ IL-10 ） and high sensitivity C-reactive protein（hs-CRP） were compared between the two groups. Results There was no significant difference in the levels of CK-MB,cTnl and h-FABP between the two groups before PCI（P 〉0.05）. The levels of CK-MB and cTnI after PCI were significantly higher than those before PCI in control group（ P 〈 0.05 ）. But there was no significant difference in h-FABP level before and after PCI in control group（ P 〉 0.05 ）. There was no significant difference in the levels of CK-MB, cTnI and h-FABP before and after PCI in observation group（ P 〉 0.05 ）. The levels of CK-MB and cTnI in observation group were significantly lower than those in control group after PCI （P 〈 0.05 ）. But there was no significant difference in h-FABP level between the two groups after PCI （ P 〉 0.05 ）. There was no significant difference in the levels of TNF-α, INF-γ, IL-10 and hs-CRP between the two groups before PCI（ P 〉 0.05 ）. The hs-CRP level after PCI was significantly higher than that before PCI in the two groups （P 〈 0.05 ）. The IL-10 level after PCI was significantly higher than that before PCI in control group（ P 〈 0.05 ）. The levels of IL-10 and hs-CRP in observation group were significantly lower than those in control group