超小剂量肝素佐治新生儿缺氧缺血性脑病并全身炎症反应综合征76例

目的探讨超小剂量肝素佐治新生儿缺氧缺血性脑病(HIE)合并全身炎症反应综合征(SIRS)的疗效及对C-反应蛋白(CRP)、D-二聚体(D-D)的影响。方法选择HIE合并SIRS新生儿76例作为治疗组,采用常规治疗联合超小剂量肝素;选择同期HIE合并SIRS新生儿50例作为对照组,采用常规治疗。观察两组CRP、D-D治疗前后的变化。结果与对照组比较,治疗组合并SIRS持续时间>3 d的例数显著减少(P<0.01),多脏器功能不全综合症(MODF)的发生率及死亡率显著降低(P<0.01);两组治疗后CRP、D-D比较均有显著性差异(P<0.05)。结论超小剂量肝素佐治新生儿HIE合并SIRS疗效肯定,可显著改善预后。

Efficacy of ultra-low-dose heparin as an assisted treatment for neonatal hypoxic-ischmic encephylopathy complicated by systemic inflammatory response syndrome

Objective To investigate the efficacy of ultra-low-dose(ULD)heparin as an assisted treatment for neonatal hypoxic-ischmic encephlopathy(HIE) complicated by systemic inflammatory response syndrome(SIRS),and the changes of C-reactive protein(CRP) and D-dimer(D-D) pre-and post-treatment.Methods The route treatment and ULD heparin were applied in treating group of 76 neonatal with HIE compolicated by SIRS;In the control group,50 neonatal with HIE compolicated by SIRS in the corresponding time were only treated with route treatment.The change of CRP and D-D pre-and post-treatment between two groups were compared.Results Compared with control group,the patients in treating group,whose duration of SIRS was > 3 days,were significantly reduced(P<0.01);the motality and the appearance rate of multi-organ dysfunction syndrome(MODS) were significantly lower(P<0.01);There were significant differences of CRP and D-D after treatment between two groups(all P<0.05).Conclusion The efficacy of ULD heparin as an assisted treatment for neonatal HIE complicated by SIRS is confirmed,and it may improve significantly prognosis of these patients.