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原发性肝癌切除后双途径化疗预防复发疗效分析
引用本文:张华甫,王霞,王亚奇.原发性肝癌切除后双途径化疗预防复发疗效分析[J].新乡医学院学报,2009,26(6):601-603.
作者姓名:张华甫  王霞  王亚奇
作者单位:驻马店市中心医院普外二科,河南,驻马店,463000
摘    要:目的探讨原发性肝癌根治切除术后肝动脉、门静脉双途径栓塞化疗对肝癌复发的防治效果。方法118例原发性肝癌根治性切除术后患者,采用经脐静脉途径门静脉化疗(PVC)和肝动脉化疗栓塞(HACE)35例(PVC+HACE组),单纯HACE 48例(HACE组),未做特殊处理35例(对照组);观察3组患者1~5 a生存率和复发率。结果PVC+HACE组和HACE组总复发率明显低于对照组,PVC+HACE组总复发率明显低于HACE组,差别均有统计学意义(P<0.05)。PVC+HACE组1 a生存率明显高于对照组,差别有统计学意义(P<0.05),但PVC+HACE组和HACE组比较差别无统计学意义(P>0.05)。PVC+HACE组2~5 a生存率均明显高于HACE组和对照组,差别均有统计学意义(P<0.05)。结论原发性肝癌根治切除术后肝动脉、门静脉双途径栓塞化疗可有效降低复发率,提高生存率。

关 键 词:原发性肝癌  肝动脉  门静脉  化疗  栓塞

Prevention recurrence of combining hepatic artery chemoembolization and portal vein chemotherapy on primary hepatic carcinoma after radical excision
ZHANG Hua-fu,WANG Xia,WANG Ya-qi.Prevention recurrence of combining hepatic artery chemoembolization and portal vein chemotherapy on primary hepatic carcinoma after radical excision[J].Journal of Xinxiang Medical College,2009,26(6):601-603.
Authors:ZHANG Hua-fu  WANG Xia  WANG Ya-qi
Institution:(Department of General Surgery, Zhumadian Central People's Hospital, Zhumadian 463000, China)
Abstract:Objective To evaluate the effect of combining hepatic artery chemoembolization (HACE) and portal vein chemotherapy (PVC) after radical resection of primary hepatic carcinoma (PHC) to prevent recurrence. Methods One hundred and eighteen patients with PHC were divided into three groups after radical resection. Thirty-five patients in PVC + HACE group were treated with HACE and PVC, HACE alone in HACE group(48 cases), nothing in control group(35 cases). The survival rate and recurrence rate were observed. Results The total recurrence rate in PVC + HACE group and HACE group was lower than that in control group(P 〈0. 05) ,it was lower in PVC + HACE group than that in HACE group(P 〈0.05). The recurrence rate at one year after surgery was significantly lower in PVC + HACE group and HACE group than that in control group( P 〈 0.05 ), but there was no obvious difference in the recurrence rate between the PVC + HACE group and HACE group (P 〉 0.05). From two to five years,the recurrence rate was lower in PVC + HACE group than that in FIACE group and control group (P 〈 0. 05). Conclusion After radical resection of PHC, combined use of HACE and PVC can reduce recurrence rate and increase survival rate.
Keywords:primary hepatic carcinoma  hepatic artery  portal vein  chemotherapy  chemoembolization
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