| 人食管鳞癌中淋巴管的表达密度及意义 |
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| 引用本文： | 时景文,庞霞,张红新,宋一民,高冬玲,陈奎生.人食管鳞癌中淋巴管的表达密度及意义[J].新乡医学院学报,2006,23(4):338-340. |
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| 作者姓名： | 时景文 庞霞 张红新 宋一民 高冬玲 陈奎生 |
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| 作者单位： | 1. 郑州煤炭集团总医院病理科,河南,新密,452371
2. 郑州大学第一附属医院病理科,河南省肿瘤病理重点实验室,河南,郑州,450052 |
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| 基金项目： | 河南省高校杰出科研人才创新工程项目 |
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| 摘 要： | 目的探讨血管内皮生长因子受体3(VEGFR-3)在人食管鳞癌中的表达及其在淋巴管生成和淋巴结转移中的临床意义。方法采用免疫组织化学SP法,检测59例食管鳞癌手术标本组织中VEGFR-3的表达及定位特征,并用图像分析方法测定淋巴管数量和平均光密度(MOD),及其与淋巴结转移的关系。结果VEGFR-3表达与肿瘤淋巴结转移密切相关(P<0.05),癌组织和癌周组织VEGFR-3阳性淋巴管密度(LVD)和MOD也与淋巴结转移密切相关(P<0.01)。结论VEGFR-3与淋巴结转移、新生淋巴管的形成有相关性。
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| 关 键 词： | 食管鳞状细胞癌 血管内皮生长因子受体-3 淋巴转移 免疫组织化学 图像分析 |
| 文章编号： | 1004-7239（2006）04-0338-03 |
| 收稿时间： | 2005-11-04 |
| 修稿时间： | 2005-11-04 |
Density of lymphatic vessels and its clinical significance in human esophageal squamous cell carcinoma |
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| SHI Jing - wen, PANG Xia, ZHANG Hong- xin, et al.Density of lymphatic vessels and its clinical significance in human esophageal squamous cell carcinoma[J].Journal of Xinxiang Medical College,2006,23(4):338-340. |
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| Authors: | SHI Jing - wen PANG Xia ZHANG Hong- xin |
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| Institution: | 1. Department of Pathology, Zhengzhou Coal Group General Hospital, Xinmi 452371, China ; 2. Department of Pathology, the First Affiliated Hospital, Zhengzhou University, Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052, China |
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| Abstract: | Objective To study the relationship between the expression of vascular endothelial growth factor receptor 3(VEGFR-3) and lymphangiogenesis in human esophageal squamous cell carcinoma(ESCC).Methods VEGFR-3 expression in ESCC tissues from 59 cases was detected by the immunohistochemical SP method and the image analysis system.The relationship between VEGFR-3 and lymphangiogenesis was analyzed by calculating the number of lymphatic vessel density(LVD).Results There was a statistically positive correlation between VEGFR-3 expression and lymph node metastasis in primary tumors(P<0.05).The number and mean optical density(MOD) of VEGFR-3 positive lymphatic vessels in the tumor and peritumoral tissue were also closely related to the lymph node metastasis of ESCC(P<0.01).Conclusion There is a close relationship between VEGFR-3 and lymphangiogenesis in ESCC. |
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| Keywords: | esophageal squamous cell carcinoma VEGFR-3 lymphatic metastasis immunohistochemistry image analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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