| 地方性氟中毒氟骨症发生的分子机理研究进展 |
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| 引用本文： | 王守英,席景砖,张合喜,喻茂娟.地方性氟中毒氟骨症发生的分子机理研究进展[J].新乡医学院学报,2005,22(5):521-522. |
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| 作者姓名： | 王守英 席景砖 张合喜 喻茂娟 |
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| 作者单位： | 1. 新乡医学院,河南,新乡,453003
2. 贵阳医学院,贵州,贵阳,550004 |
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| 基金项目： | 国家自然科学基金项目（编号：30260099） |
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| 摘 要： | 目的了解氟骨症发生的分子机理的研究现状和发展趋势。方法应用现代信息技术,通过互联网等,收集有关文献资料,对目前国内外有关氟骨症最新论著进行综合分析。结果骨形成相关基因和骨吸收相关基因与氟骨症的发生密切相关。结论深入研究氟骨症的分子发病机制,尤其是小儿氟骨症的分子发病机制,对于制定氟骨症的早期预防和控制措施具有重要的意义。
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| 关 键 词： | 地方性氟中毒 氟骨症 分子机理 |
| 文章编号： | 1004-7239（2005）05-0521-02 |
| 收稿时间： | 2005-06-05 |
| 修稿时间： | 2005-06-05 |
Study advancement on molecular mechanism of endemic fluorosis with skeletal fluorosis |
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| Wang ShouYing;Xi JingZhuan;Zhang GeXi;Yu MaoJuan.Study advancement on molecular mechanism of endemic fluorosis with skeletal fluorosis[J].Journal of Xinxiang Medical College,2005,22(5):521-522. |
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| Authors: | Wang ShouYing;Xi JingZhuan;Zhang GeXi;Yu MaoJuan |
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| Institution: | ZengShu;ShenJiao |
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| Abstract: | Objective To explore the current research and the developing trend on molecular mechanism of endemic fluorosis skeletal fluorosis. Methods The domestic and foreign latest documents and information collected through modem information techniques and the Intemet were treated with aggregate analysis. Results There was close relationship between the development of skeletal fluorosis and bone formation related gene and bone resorption related gene. Conclusion It may play an important role in the early prophylaxis and control measures studying the molecular mechanism of endemic fluorosis skeletal fluorosis especially in children. |
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| Keywords: | endemic fluorosis skeletal fluorosis molecular mechanism |
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