Survivin在食管鳞癌发生发展中的作用

目的研究Survivin在食管正常黏膜、不典型增生及食管鳞癌中的表达,分析Survivin蛋白表达与患者临床病理特征及预后之间的关系。方法83例食管鳞癌患者采用免疫组织化学方法检测Survivin蛋白在不同病变组织中的表达情况,随访5a以上。结果Survivin蛋白在正常黏膜、不典型增生及鳞癌组织呈渐进性高表达(P<0.001)。Survivin蛋白表达与食管癌的浸润程度、pTNM分期显著相关(P<0.05)。Survivin阳性表达患者的5a生存率明显低于阴性表达患者(P<0.05),Cox回归模型多因素分析显示,Survivin阳性表达是影响食管癌患者术后生存的独立预后因素(RR=3.125,P<0.05)。结论Survivin表达与食管癌的发生发展密切相关,可作为食管癌早期诊断指标;Survivin表达可能是影响食管癌患者预后的独立因素。

Role of Survivin in carcinogenesis and development of esophageal squamous-celled carcinoma

Objective To study the expression of Survivin proteins in normal esophageal mucosa,atypical hyperplasia tissue and esophageal squamous cell carcinoma （ESCC） and to analyze the relationship between protein expession and clinicopathologic characteristic. Methods The expression of Survivin in different pathological changed tissue of 83 cases with esophageal squamous-celled carcinoma was detected by immunohistochemistry, and they all followed up more than 5 years. Results The expression of Survivin were progressively increasing in the course from normal, atypical hyperplasia to squamous cell carcinoma （ P 〈 0. 001 ）. It was significantly correlated with tumor infiltration depth and pTNM staging（ P 〈 0. 05 ）. The 5-year overall survival rate of Survivin positive patients was lower than that of Survivin negative patients （P 〈 0. 05 ） ;By Cox regression model multivariate analysis, the positive expressin of Survivin was the independent prognostic factors for ESCC patients（ RR = 3. 125, P 〈 0. 05 ）. Conclusion The expression of Survivin was significantly related to the occurrence and progression of ESCC, it may be an important marker for ESCC early diagnosis, and it may be an independent prognostic indicator for ESCC patients.