| 阿西美辛固体分散体大鼠在体肠道吸收动力学的研究 |
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| 引用本文： | 刘振华,李忠思.阿西美辛固体分散体大鼠在体肠道吸收动力学的研究[J].承德医学院学报,2003,20(3):199-200. |
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| 作者姓名： | 刘振华 李忠思 |
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| 作者单位： | 1. 承德医学院附属医院,河北,承德,067000
2. 承德中药集团有限责任公司 |
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| 摘 要： | 目的：考察阿西美辛固体分散体在大鼠不同肠段的吸收动力学特征及不同的药物浓度的影响。并与阿西美辛混悬液进行比较。方法：采用大鼠在体肠吸收实验方法。结果：阿西美辛固体分散体在十二指肠、回肠的吸收量分别为0．9294，0．5043cm^2／h。不同药物浓度：0．05，0．1，0．5，1．0mg／ml在回肠的吸收速率常数分别为0．4798，0．5025，0．5570，0．6306cm^2／h。结论：阿西美辛固体分散体比阿西美辛混悬液在肠道中的吸收量大；药物浓度对吸收速率常数无影响；吸收机制为被动扩散。
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| 关 键 词： | 阿西美辛固体分散体 大鼠 体肠道吸收 动力学 吸收速率常数 |
| 文章编号： | 1004-6879(2003)03-0199-02 |
| 修稿时间： | 2003年3月30日 |
STUDIES ON THE ABSORPTION KINETICS OF ACEMETACIN SOLID DISPERSION IN RATS' INTESTINE |
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| LIU Zhen-hua,LI Zhong-si.STUDIES ON THE ABSORPTION KINETICS OF ACEMETACIN SOLID DISPERSION IN RATS'''' INTESTINE[J].Journal of Chengde Medical College,2003,20(3):199-200. |
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| Authors: | LIU Zhen-hua LI Zhong-si |
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| Abstract: | Objective: To investigate the absorption kinetics of acemetacin solid dispersion (AM - SD) at different intestine segments in rats and the influence of concentration. Methods: The intestine in rats was cannulated for in situ recirulation. Results: The permeability of AM - SD in duodenum and ileum were 0. 9294 and 0. 5043 cm2/h respectively. K value at the concentrations of 0. 05, 0.1, 0. 5, 1.0 mg/ ml from ileum were 0. 4798, 0. 5025, 0. 5570, 0. 6306 cm2/h. Conclusion: AM-SD is more absorbed at different intestine segments in rats than Am suspension, concentration has no effect on the absorption kinetics. The mechanism of AM-SD absorption may be passive diffusion. |
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| Keywords: | AM-SD In situ absorption from intestine Absorption rate constant |
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