茶多酚对石英粉尘和烟溶液致大鼠氧化损伤治疗作用的研究

目的:研究茶多酚(TP)对石英粉尘、烟溶液所致大鼠脂质过氧化损伤的保护作用.方法:雄性Wistar大鼠随机分为5组,检测各组大鼠血液中一氧化氮(NO)、丙二醛(MDA)和肺胶原的含量及谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的活性.结果:大鼠染粉尘与烟溶液后,NO、MDA和肺胶原含量明显升高(与对照组比较:P<0.01),GSH-Px、SOD、CAT活性显著下降(与对照组比较:P<0.01),喂饲TP后各值均趋向正常.结论:茶多酚可以拮抗粉尘及烟溶液中有害物质引起的脂质过氧化损害,提高机体抗氧化酶的活性.

EFFECTS OF TEA POLYPHENOLS ON OXIDATIVE DAMAGES INDUCED BY SILICON AND CSS IN RATS

Objective:To study the effects of tea polyphenols (TP) on oxidative damages induced by silicon and cigarette smoking solution(CSS) in rats. Methods:Wistar rats were used in this study and divided into 5 groups at random. The contents of nitric oxide (NO), malanyldiaehyde (MDA), giutathione peroxidease (GSH-Px), superoxiet dismutase (SOD), catalase (CAT) in blood and contents of pulmonary collage in lung tissue were detected.Results:After the rats were exposed to silicon and CSS, the level of NO, MDA in blood and contents of pulmonary collage in lung tissue increased obviously(compared with control:P<0.01), the activities of GSH-Px , SOD, CAT decreased obviously(compared with control:P<0.01). These indexes tended to normal after taking TP.Conclusions:TP can prevent oxidative damages and intensify activities of antioxidant enzyme.