| 血管紧张素转换酶和血管紧张素原基因多态性与冠心病相关性研究 |
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| 引用本文： | 王士强,吴延庆,程晓曙,程开诚,陈琦,吴清华,姜醒华. 血管紧张素转换酶和血管紧张素原基因多态性与冠心病相关性研究[J]. 南昌大学学报(医学版), 2010, 50(8) |
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| 作者姓名： | 王士强 吴延庆 程晓曙 程开诚 陈琦 吴清华 姜醒华 |
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| 作者单位： | 王士强,WANG Shi-qiang(淮北市人民医院心内科,安徽,淮北,235100);吴延庆,程晓曙,程开诚,陈琦,吴清华,姜醒华,WU Yan-qing,CHENG Xiao-shu,CHENG Kai-cheng,CHEN Qi,WU Qing-hua,JIANG Xing-hua(南昌大学第二附属医院心内科,南昌,330006) |
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| 摘 要： | 目的探讨血管紧张素转换酶和血管紧张素原基因多态性与冠心病的关系。方法选取270例江西籍汉族住院病人,根据造影结果分成冠心病组(至少有1支冠状动脉狭窄≥70%)161例,对照组(冠状动脉造影正常)109例。酚/氯仿/无水乙醇法提取基因组DNA。聚合酶链式反应(PCR)和基因突变聚合酶链反应(MS-PCR)技术及琼脂电泳检测ACEI/D、AGTM235T基因多态性。结果冠心病组ACEI/DDD基因型频率和D等位基因频率、AGTM235T TT基因型频率和T等位基因频率显著高于对照组(P<0.05或P<0.01)。Logistic回归分析冠心病的独立危险因素结果表明:ACE/DD和AGT/TT基因型是冠心病和心肌梗死的危险因子(P<0.05)。含有TT和至少一个D等位基因的基因型组合较其他几种基因型组合,冠心病和心肌梗死发病的危险性更高(P<0.05或P<0.01)。结论 ACEI/DDD型和D等位基因、AGTM235T TT型和T等位基因是冠心病发病的危险因素。含有TT和至少一个D等位基因的基因型组合较其他几种基因型组合,冠心病和心肌梗死发病的危险性更高。
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| 关 键 词： | 血管紧张素转换酶 血管紧张素原 多态性 冠状动脉造影 冠心病 |
Relationship between Angiotensin-converting Enzyme and Angiotensinogen Gene Polymorphism and Coronary Artery Disease |
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| WANG Shi-qiang,WU Yan-qing,CHENG Xiao-shu,CHENG Kai-cheng,CHEN Qi,WU Qing-hua,JIANG Xing-hua. Relationship between Angiotensin-converting Enzyme and Angiotensinogen Gene Polymorphism and Coronary Artery Disease[J]. Journal of Nanchang University(Medical Science), 2010, 50(8) |
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| Authors: | WANG Shi-qiang WU Yan-qing CHENG Xiao-shu CHENG Kai-cheng CHEN Qi WU Qing-hua JIANG Xing-hua |
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| Affiliation: | WANG Shi-qiang1,WU Yan-qing2,CHENG Xiao-shu2,CHENG Kai-cheng2 CHEN Qi 2,WU Qing-hua2,JIANG Xing-hua2(1.Department of Cardiovasology,the People's Hospital of Huaibei,Huaibei 235100,China,2.Department of Cardiovasology,the Second Affiliated Hospital Nanchang University,Nanchang330006,China) |
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| Abstract: | Objective To explore the relationship between angiotensin-converting enzyme(ACE)and angiotensinogen(AGT)gene polymorphism and coronary artery disease(CAD).Methods A total of 270 Han Chinese patients from Jiangxi province who underwent coronary angiography(CAG)were divided into control group(normal CAG,109 patients)and CAD group(at least stenosis greater than or equal to 70% in one coronary artery,161 patients).DNA was extracted by phenol/chloroform/absolute alcohol methods.Polymorphysim of ACE I/D and AGT M... |
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| Keywords: | angiotensin-converting enzyme angiotensinogen polymorphism coronary angiography coronary artery disease |
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