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有遗传史的原发性高血压患者子代血清白介素-6和肿瘤坏死因子-α浓度的比较性研究
引用本文:唐蕊,李海涛,林晓娥,刘芳,王爱红,严爱民. 有遗传史的原发性高血压患者子代血清白介素-6和肿瘤坏死因子-α浓度的比较性研究[J]. 中国煤炭工业医学杂志, 2014, 0(1): 1-3
作者姓名:唐蕊  李海涛  林晓娥  刘芳  王爱红  严爱民
作者单位:[1]唐山工人医院分院,河北省唐山市063000 [2]河北联合大学附属医院心内科,河北省唐山市063000
基金项目:河北省科技厅课题基金(项目编号:12276104D-52)
摘    要:目的探讨白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)在有遗传史的原发性高血压(EH)子代中的作用及临床意义。方法用ELISA方法检测有EH遗传史的患者及其子代和正常人群及其子代血清IL-6、TNF-α水平,并将二者进行比较。结果①高血压患者比正常人群血清IL-6、TNF-α明显升高(P〈0.01),②有高血压遗传史的子代和正常人群的子代相比,前者血清IL-6、TNF-α高于后者(P〈0.05)。结论高血压患者血清IL-6、TNF-α升高,而在他们血压正常的子代中也增高,提示:高血压可引起机体内血清IL-6、TNF-α水平升高,从而参与和促进了高血压的发展,这种高的IL-6、TNF-α水平可能与遗传有关。

关 键 词:高血压  遗传史  肿瘤坏死因子-α  白介素-6

HYPERTENSION GENETIC HISTORY
Affiliation:Tang Rui , Li Haitao , Lin Xiao'e ,et al. Department of Cardiology, The Branch of Tangshsan Gong Ren Hospital, Tangshan 063000, China
Abstract:Objective To discuss the clinical significance of offspring serum in IL - 6 and TNF-α of EH with genetic history. Methods The IL- 6 and TNF-α were detected on EH patients with genet- ic history and their offspring and those of normal people and their offspring by ELISA. Results Compared with normal people, EH patients had much clearer increase in IL- 6 and TNF-α(P〈0.01). Compared with offspring of normal people, offspring of EH patient with genetic history had much higher IL- 6 and TNF-α(P〈0.05). Conclusions EH patients have an increased in IL- 6 and TNF -α, while their offspring with normal hypertension have an increased in IL- 6 and TNF-α as well, which can be indicated that EH is responsible for the increase of IL - 6 and TNF -α and get involved and increase the development of EH. The high level of IL- 6 and TNF-α can be related to genetic factors.
Keywords:EH  Genetics  IL- 6  TNF-α
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