中期妊娠羊膜腔内注射依沙吖啶引产出血的高危因素

目的 采用羊膜腔内注射依沙吖啶终止中期妊娠，分析其引产出血的高危因素。方法 选取同济大学附属第一妇婴保健院计划生育科2017年2月—2018年2月327例中期妊娠采用依沙吖啶引产患者，孕周在16～26周，收集患者年龄、孕周、双顶径、引产原因、前次分娩方式、既往孕次、胎盘位置、胎盘娩出情况、胎儿情况等临床资料，回顾性分析以上因素与引产出血量的相关性。结果 中期妊娠引产后出血受多因素影响，胎盘因素（胎盘粘连）是最主要高危因素，居于首位，其次为胎儿因素（双胎及死胎），最后为既往孕次。结论 依沙吖啶引产术前充分了解病史、评估高危因素，采取恰当的处理，对引产成功、减少出血并发症发生具有重要意义。

Risk factors of bleeding in termination of midtrimester pregnancy with intraamniotic injection of ethacridine lactate

Objective To analyze the risk factors of bleeding in termination of midtrimester pregnancy with intraamniotic injection of ethacridine lactate. Methods The labor induction by intraamniotic injection of ethacridine lactate was performed in 327 pregnant women with gestation of 16 to 26 weeks in Shanghai First Maternity and Infant Hospital, Tongji University from February 2017 to February 2018. The association of maternal, fetal and placental factors with the volume of blood loss during labor induction was analyzed. Results Postpartum hemorrhage was affected by multiple factors during induced labor, and placental factors were the most important risk factors, followed by fetal factors (twin and stillbirth), and the history of previous pregnancy. Conclusion To reduce the postpartum bleeding, it is necessary to evaluate the risk factors and take appropriate treatment before induced labor with ethacridine lactate.