| LOXL-1与盆底器官脱垂的关系 |
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| 引用本文： | 施腾飞,童晓文.LOXL-1与盆底器官脱垂的关系[J].同济大学学报(医学版),2013,34(5):121-124. |
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| 作者姓名： | 施腾飞 童晓文 |
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| 作者单位： | 同济大学附属同济医院妇产科,上海200065 |
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| 基金项目： | 上海市科委项目（09DZ1950300） |
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| 摘 要： | 盆底器官脱垂（pelvicorganprolapse，PoP）是以盆底支持组织薄弱为特性的-类功能障碍性疾病，其发生是-个复杂的过程。盆底组织内弹性纤维结构或功能异常可直接导致POP的发生。类赖氨酰氧化酶-1（1ysyloxidase—likeprotein-1，LOXL-1）是弹性蛋白保持正常结构功能的关键酶。LOXL-1缺失或功能障碍，将导致弹性纤维功能紊乱，从而引起POP。本研究就LOXL-1在POP发生机制中的作用进行综述。
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| 关 键 词： | 盆底器官脱垂 弹性纤维 弹性蛋白 类赖氨酰氧化酶-1 |
Association of LOXL-1 enzyme with pelvic organ prolapse |
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| SHI Teng-fei and TONG Xiao-wen.Association of LOXL-1 enzyme with pelvic organ prolapse[J].Journal of Tongji University(Medical Science),2013,34(5):121-124. |
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| Authors: | SHI Teng-fei and TONG Xiao-wen |
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| Institution: | (Dept. of Gynecology and Obstetrics,Tongji Hospital, Tongji University, Shanghai 200065, China) |
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| Abstract: | Pelvic organ prolapse （POP） is a functional disorder characterized by weak pelvic support tissue. A variety of factors are involved in development of POP, among which the abnormal structure or function of elastic fiber in pelvic floor tissues can directly lead to POP. Lysyl oxidase-like protein-1 （LOXL-1） is a key enzyme to keep normal structure and function of elastin dysfunction of LOXL-1 will lead to dysfunction of the elastic fibers, causing reviews the role of LOXL-1 in the development POP and its mechanism. Therefore, missing or the POP. The article |
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| Keywords: | pelvic organ prolapse elastic fibers elastin lysyl oxidase-like protein-1 |
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