氟康唑与5-氟胞嘧啶体外联合抗白念珠菌临床分离株的研究

目的评价白念珠菌临床分离株对氟康唑和5-氟胞嘧啶联合用药的敏感性及判断两药物之间相互作用的方式。方法采用美国国家临床实验室标准化委员会（NCCLS）M27-A推荐的棋盘微量稀释法，检测了30株白念株菌临床分离株对氟康唑、5-氟胞嘧啶及两药联合的体外药物敏感性，同时对两药的作用方式进行判定。结果联合用药时显著减少了每一药物MIC值的几何均数，在40％受试菌表现为协同作用方式，在53．3％的受试菌株表现为相加作用方式，在6．7％受试菌株表现为无关作用方式，未观察到拮抗作用出现。结论氟康唑和5-氟胞嘧啶联合比单一药物体外抗白念珠菌的活性高。

Sensitivity of Combination Effect of Fluconazole with Flucytosine Against Isolates of Candida Albicans

Objective To study the sensitivity of 30 clinical Candida albicans to the combination effect of fluconazole with flucytosine. Methods A checkerboard titration broth rnicrodilution-based method that adhered to the recommendations of the National Committee for Clinical Laboratory Standards was applied to study the sensitivity of 30 clinical isolates of Candida albicans. Results When fluconazole and flucytosine were given incombination, there were significant reductions in the geometric mean fluconazole MIC. and flucytosine MIC. For 40 % of the isolates the interactions were synergistic, for 53.3 % they were additive, and for 6.7 % they were indifferent, while antagonism was not obeserved. Conclusion The combination effect of fluconazole and flucytosine is significantly more activethan any drug alone against Candida albicans in vitro.