缺血预适应对心肌缺血／再灌注损伤中细胞凋亡的作用

目的：探讨心肌缺血/再灌注损伤早期细胞凋亡的分布情况及缺血预适应的心肌保护作用是否与减少缺血区凋亡的发生有关。方法：将新西兰兔制成急性心肌缺血/再灌注损伤动物模型，随机分为两组：IR组和IP组。分区取心肌组织标本进行梗死面积大小及凋亡指数的检测。结果：IP组的梗死面积大小及凋亡指数均明显低于IR组。结论：心肌缺血/再灌注损伤早期细胞凋亡主要发生在缺血区的心肌组织中，缺血预适应可明显减少其发生。

The Effects of Ischemic Preconditioning on Apoptosis in Myocardial Ischemia Reperfusion Injury

Objective To discuss the distribution of myocyte apoptosis at the early stage of myocardial ischemia reperfusion injury; and to know whether the myocardial preservation effect of ischemic preconditioning related to the reduction of apoptosis within ischemia area.Methods The animal models of myocardial ischemia reperfusion injury made from New Zealand white rabbits were randomly divided into two groups:IR group and IP group.Infarct size and apoptosis index were detected in heart tissue specimen from different areas.Results In IP group, infarct size and apoptosis index were all lower than that in IR group.Conclusion The myocyte apoptosis mostly exists within the ischemia area at early stage of myocardial ischemia reperfusion injury;ischemic preconditioning can greatly decrease its occurrence.