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营养性肥胖大鼠模型的建立及评价
引用本文:汤锦花,严海东.营养性肥胖大鼠模型的建立及评价[J].同济大学学报(医学版),2010,31(1):32-34.
作者姓名:汤锦花  严海东
作者单位:同济大学附属东方医院肾内科,上海,200120
摘    要:目的高脂饲料喂养诱导营养性肥胖大鼠模型的建立及评价。方法将45只成年sD大鼠随机分为正常模型组(n=40)和对照组(n=5),分别给与基础饲料和高脂饲料喂养8周,检测大鼠体重、体长、体重指数(bodymassindex,BMI)、血糖及总胆固醇(cholesterol,CHO)、甘油三酯(triglyceride,TG)、高密度脂蛋白(highdensity lipoprotein—cholesterol,HDL—C)及低密度脂蛋白(low density lipoprotein—cholesterol,LDL-C)。结果通过高脂饲料喂养后,模型组大鼠体重、BMI与对照组比较差别均有统计学意义(P〈0.05,P〈0.01);其总胆固醇及LDL—C明显高于对照组(P〈0.05,P〈0.01),HDL—C则明显低于对照组(P〈0.01),造模过程中,甘油三酯两组差别无统计学意义;模型组大鼠存在糖耐量异常。结论通过高脂饲料喂养可诱导出符合或贴近临床的营养性肥胖大鼠模型。

关 键 词:高脂饲料  肥胖  动物模型

Establishment and evaluation of rats model with nutritional obesity
TANG Jin-hua and YAN Hai-dong.Establishment and evaluation of rats model with nutritional obesity[J].Journal of Tongji University(Medical Science),2010,31(1):32-34.
Authors:TANG Jin-hua and YAN Hai-dong
Institution:TANG Jin-hua,YAN Hai-dong (Dept.of Nephrology,East Hospital,Tongji University,Shanghai 200120,China)
Abstract:Objective To establish and evaluate the high-fat-induced obese rat model.Methods Forty-five adult Sprague-Dawley rats were randomized into model group(n=40) and normal group (n=5) with high-fat diet and standard diet for 8 weeks,respectively.Measurements of body weight, body length,body mass index(BMI),blood glucose and total cholesterol(CHO),triglyceride(TG), high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) were performed.Results There were statistically significant di...
Keywords:high-fat diet  obesity  animal models  
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