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新生儿ABO溶血病与孕妇抗体效价关系的研究
引用本文:覃小青,焦伟,朱春丽,申卫东.新生儿ABO溶血病与孕妇抗体效价关系的研究[J].医学文选,2005,24(4):471-473.
作者姓名:覃小青  焦伟  朱春丽  申卫东
作者单位:[1]广西壮族自治区人民医院,南宁530021 [2]南宁市中心血站,南宁530021
摘    要:目的探讨孕妇血型抗体效价与新生儿溶血病(HDN)的关系。方法对ABO血型不合的510对夫妇作ABO、RH(D)血型检查及血型抗体效价检测。以抗体效价〉64为观察对象,观察254例孕妇血型抗体效价的变化,了解新生儿HDN发病情况,并对165例怀疑有高胆血症的新生儿进行检测。结果510对夫妇中,妇夫血型为O-A的204对(39.92%),血型为O-B的240对(46,96%),O—AB的59对(11.57%),A—B的2对(0.39%),A-O、B—O、AB—B共5对(9.80%)。ABO血型效价〉64的占49.6%。抗体效价〉256的HDN发病率高达31.25%,HDN者20例(12.12%),均为ABO溶血。结论孕妇血型IgG抗体效价高,HDN发病可能性大。孕妇夫妇血型检查和夫妇血型不合者的孕妇血型IgG抗体检测,有助于HDN的产前预测。

关 键 词:孕妇  血型抗体  新生儿溶血病
文章编号:1003-952(2005)04-0471-03

Study of the Relation ship between ABO Hemolysis Disease of Newborn and Maternal antibody
Qin XiaoQing;Jiao Wei;Zhu ChunLi;Shen WeiDong.Study of the Relation ship between ABO Hemolysis Disease of Newborn and Maternal antibody[J].Anthology of Medicine,2005,24(4):471-473.
Authors:Qin XiaoQing;Jiao Wei;Zhu ChunLi;Shen WeiDong
Abstract:Objective To investigate the relation ship between ABO Hemolysis Disease of Newborn (HDN) and maternal antibody.Methods Blood type and the titer of blood group antibody of 510 couples were determined to observe the change of the titer of blood group maternal antibody which exceeded 64 and find out the incidence of HDN.165 suspected with hypercholesterolemia were examined.Results Of 510 couples, 204 couples were O-A (39.92%), 240 O-B(46.96%),59 O-AB(11.57%),2 A-B(0.39%). The rate of the titer of ABO blood group(>64) was 49.6%. The incidence of HDN(the titer of antibody>256) was 31.25%. There were 20 cases of ABO HDN(12.12%).Conclusion When the titer of IgG maternal antibody increases, the incidence of HDN will increase. It will be helpful for antenatal prediction of HDN to determine blood type in couples and IgG maternal antibody.
Keywords:Maternal  Blood group antibody  Hemolytic disease of newborn
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