心肌血流储备分数在冠状动脉临界病变患者中的应用

目的 探讨心肌血流储备分数（FFR）处于临界值（0.75～0.80）时应用不同的治疗策略对生活质量的影响.方法 对60例冠状动脉造影显示冠状动脉病变（狭窄70%～75%） 并且FFR处于临界值的冠心病患者随机分为经皮冠状动脉介入治疗组（PCI组,n=30）和药物治疗组（保守组,n=30）进行治疗,平均随访6个月,观察两组主要不良心血管事件（MACE）和西雅图心绞痛量表（SAQ）情况.结果 PCI组和保守组对MACE和SAQ的影响差异无统计学意义（P＞0.05）.结论 狭窄程度达70%～75%的冠状动脉病变若FFR处于临界值（0.75～0.80）,仍可安全地给予药物保守治疗.

Application of myocardial fractional flow reserve in patients with borderline coronary artery disease

Objective To evaluate the effect of different treatment strategies on life quality in patients with myocardial fractional flow reserve （FFRmyo） at critical point （0.75 -0.80）. Methods Sixty coronary artery disease （CAD） patients with 70 -75% coronary artery stenosis on angiography and FFRmyo at critical point （0.75-0.80） were randomized into two groups：30 patients underwent coronary artery stenting （PCI group）, and 30 patients received pure drug therapy. Patients were followed up to 6 months. Major adverse cardiac events （MACE） and Seattle angina questionaire （SAQ） were primary endpoints. Results Differences in MACE incidence and SAQ scores between two groups were not significant （ P 〉 0.05）. Conclusion Pure drug therapy can be used in patients with lesion of 70% - 75% stenosis and FFRmyo at critical point （0.75-0.80）.