冠心病患者血清脂蛋白相关磷脂酶和C反应蛋白改变及临床意义

目的探讨血清脂蛋白相关磷脂酶A2（LP—PLA2）和C反应蛋白（CRP）在冠心病发病申的作用及临床价值。方法采用双抗夹心ELISA法测定120例冠心病患者和35例健康体检者血清LP—PLA2和CRP水平。结果冠心病组血清LP—PLA2、CRP水平均显著高于对照组（t=4．157，11．152，P〈0．01）；在冠心病不同临床类型患者中，AMI组血清LP—PLA2、CRP水平显著高于UAP组、SAP组（t=3．509，3．973，4．453，7．510，P均〈0．01），UAP组血清LP—PLA2、CRP水平显著高于SAP组（t=2．998，4．466，P〈0．05）；血清LP—PLA2和CRP水平无相关性（r=0．067，P〉0．05）。结论LP—PLA2和CRP同参与了动脉粥样硬化的炎症反应，在冠状动脉粥样硬化的进程中扮演了重要的角色。

Changes of Serum LP-PLA2 and CRP in Patients with Coronary Heart Diseases and Its Clinical Significance

Objective To investigate the change of serum LP-PLA2 and CRP in patients with coronary heart diseases （ CHD ） and its clinical significance. Methods The serum LP-PLA2 and CRP level of 120 cases of CHD patients and 35 cases of healthy subjects were measured by ELISA. Results The serum LP-PLA2 and CRP levels of the CHD group were higher than the control group, compared the difference was significant （ t=4.157,11.152, P 〈 0.01 ） ; In CHD patients of different clinical types, the serum LP-PLA2 and CRP levels of AMI group were higher than the UAP group and SAP group, the difference was significant （t=3.509,3.973,4.453,7.510, P 〈 0.01 ）; The serum LP-PLA2 and CRP levels of UAP group were higher than the SAP group, the difference was significant （ t=2.998, 4.466, P 〈 0.05 ） ; The serum LP-PLA2 and CRP levels was no significantly correlated （ r=-0.067, P 〉 0.05 ）. Conclusion The serum LP-PLA2 and CRP levels participate in the atherosclerotic inflammatory response and play important role in the incidence of in the process of coronary atherosclerosis.