血浆同型半胱氨酸与临床孤立综合征的相关性研究

目的探讨多发性硬化（MS）的早期表现一临床孤立综合征（clinically isolated syndromes，CIS）患者血浆同型半胱氨酸（hornocysteine，Hcy）水平及其临床意义。方法采用荧光偏振免疫法检测CIS患者40例（CIS组）血浆中Hcy的浓度，并用放免方法检测叶酸、维生素B12，其结果与30例健康体检者（NC组）进行比较。结果CIS组血浆中Hcy水平高于NC组，差异有显著性（P〈0．05），而两组叶酸、维生素B12浓度差异无统计学意义（P〉0．05）aCIS组中脊髓型和脑干型Hcy水平相比较，差异无统计学意义（P〉0．05）。结论血浆Hcy水平与CIS有关，CIS患者Hcy水平升高，可能在CIS向MS发展的病理过程中发挥作用。

The Relationship Between Homocysteine and Clinically Isolated Syndromes

Objective To investigate the concentrations of homocysteine （ Hcy ） in plasma from patients with clinically isolated syndromes （ CIS ）, the first presentation of multiple sclerosis （ MS ） and its clinical significances. Methods Plasma Hcy levels were determinated by fluorescence polarization immunoassay （ FPLA ） technology in 40 patients （ CIS group ） and plasma folate and vitamin B12 eonstrations were detected by radioimmune assay, the results were compared with 30 healthy people. Results The mean concentration of Hcy of CIS group was significantly higher than NC group （ P 〈 0.05 ）, while there were no difference in folic acid and vitamin B12 between two groups （ P 〉 0,05 ）. There were no significant difference in Hcy between subgroups of CIS （ brainstem and spinal cord ） （ P 〉 0.05 ）. Conclusion There is an association between plasmas concentration of Hcy and CIS, the level of Hey is higher in CIS, which may contribute to the course from CIS to MS. Plasma Hcy could be one of the risk factors for CIS.