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莫西沙星与抗结核药物联用治疗难治性结核性脑膜炎的临床研究
引用本文:肖小六,钟振洲,黎昌茂,刘向红,谌微,刘明山. 莫西沙星与抗结核药物联用治疗难治性结核性脑膜炎的临床研究[J]. 中国现代医生, 2014, 0(3): 154-157
作者姓名:肖小六  钟振洲  黎昌茂  刘向红  谌微  刘明山
作者单位:[1]江西省赣州市人民医院急诊科,江西赣州341000 [2]江西省兴国县中医院内科,江西兴国342400 [3]江西省赣州市肺科医院结核科,江西赣州341000
基金项目:江西省赣州市指导性科技计划项目
摘    要:目的探讨含莫西沙星的抗痨药方案治疗结核性脑膜炎的疗效与安全性。方法对9例结核性脑膜炎患者采用含莫西沙星的抗痨药方案进行10个月的治疗,通过临床表现和辅助检查、统计学方法等手段评价其疗效与安全性。结果 9例结核性脑膜炎患者经治疗后效果良好,未留下明显的后遗症。结论莫西沙星联合其他一线抗痨药,并结合激素、脱水、改善脑功能等综合措施治疗结核性脑膜炎是安全有效的。

关 键 词:结核性脑膜炎  莫西沙星  难治性  联合用药

Clinical study on moxifloxacin combined with antituberculosis drugs in the treatment of intractable tuberculous meningitis
XIA O Xiaoliu ZHONG Zhenzhou LI Changmao,LIU Xianghong CHEN Wei,LIU Mingshan. Clinical study on moxifloxacin combined with antituberculosis drugs in the treatment of intractable tuberculous meningitis[J]. , 2014, 0(3): 154-157
Authors:XIA O Xiaoliu ZHONG Zhenzhou LI Changmao  LIU Xianghong CHEN Wei  LIU Mingshan
Affiliation:1.Emergency Department, the People's Hospital of Ganzhou City in Jiangxi Province, Ganzhou 341000, China; 2.Department of Internal Medicine, the Traditional Chinese Medicine Hospital of Xingguo County in Jiangxi Province, Xingguo 342400, China; 3.Tuberculosis Department, the Pulmonary Hospital of Ganzhou City in Jiangxi Province, Ganzhou 341000, China
Abstract:Objective To investigate the clinical curative effect and safety of the antituberculous therapy regimens containing moxifloxacin in the treatment of intractable tuberculous meningitis. Methods Nine patients with tuberculous meningitis were treated with the antituberculous therapy regimen containing moxifloxacin for 10 months course of treat- ment, the clinical curative effect and safety were evaluated by means of clinical manifestations, statistical method and auxiliary examination. Results After treatment, nine patients with tuberculous meningitis were treated with satified therapeutic results, left behind no obvious clinical sequelae. Conclusion Moxifloxacin associated with other first-line anti- tuberculosis drugs has very good curative effect and safety in the treatmenet of intractable and drug-resistant tuberculous meningitis through the combination with comprehensive measures of adjunctive corticosteroid therapy, dehydration therapy and the improvement of brain function, etc.
Keywords:Tuberculous meningitis  Moxifloxacin  Intractable  Drug combination
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