超声造影对<2 cm肝病灶的鉴别诊断价值

目的 探讨应用超声造影对2 cm肝病灶良恶性的鉴别诊断价值。方法 选取2019年6月至2020年3月在我院行肝脏常规超声和超声造影检查的患者52例,以2 cm肝病灶的患者41例为研究对象,分析两种检查方法的诊断资料,以良恶性可能性大小分为5类进行良恶性诊断及ROC曲线分析,比较两种检查方法对2 cm肝病灶良恶性的鉴别诊断价值。结果 52例肝脏超声造影患者中,2 cm肝病灶41例,占78.85%,其中有2个病灶的3例,单个病灶的38例,共计44个病灶。最终诊断恶性病灶21个,良性病灶23个,超声造影诊断的灵敏性、特异性、准确性分别为100.00%(21/21)、91.30%(21/23)、95.45%(42/44),常规超声分别为85.71%(18/21)、60.87%(14/23)、72.73%(32/44);超声造影诊断的ROC曲线下面积(0.997)大于常规超声诊断的ROC曲线下面积(0.820)(P0.05)。结论 超声造影能够全程观察病灶的造影增强及消退方式,对于直径2 cm的微小病灶,具有高灵敏性、特异性和准确性,鉴别诊断能力强,显示超声造影良好的应用前景。

Value of contrast-enhanced ultrasound in differential diagnosis of liver disease foci less than 2 cm

Objective To explore the value of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of benign and malignant liver disease foci less than 2 cm.Methods A total of 52 patients underwent routine liver ultrasound and CEUS examinations in our hospital from June 2019 to March 2020,and 41 patients with liver disease foci less than 2 cm were selected as the research subjects,and the diagnostic data of the two examination methods were analyzed.According to the probability of benign and malignant,the patients were divided into 5 categories for benign and malignant diagnosis and ROC curve analysis,and the value of the two examination methods in differential diagnosis of benign and malignant liver diseases less than 2 cm was compared.Results Among the 52 liver CEUS patients,41 patients (78.85%)had liver disease foci less than 2 cm,including 3 patients with 2 foci and 38 patients with a single focus,and a total of 44 foci were observed.A total of 21 malignant foci and 23 benign foci were finally diagnosed.The sensitivity,specificity and accuracy of CEUS were 100.00%(21/21),91.30% (21/23) and 95.45%(42/44),respectively,while those of conventional ultrasound were 85.71%(18/21),60.87%(14/23) and 72.73%(32/44),respectively.The area under the ROC curve of CEUS diagnosis (0.997) was larger than that of conventional ultrasound diagnosis (0.820,P<0.05).Conclusion Contrast-enhanced ultrasound can observe the enhanced and subsided modes of foci radiography throughout the whole process.For small foci with a diameter <2 cm,CEUS has high sensitivity,specificity and accuracy,and strong ability of differential diagnosis,showing a good application prospect.